RNA-dependent RNA polymerase of SARS-CoV-2 as a therapeutic target

被引：65
|
作者：
Wang, Yanyan [1 ]
Anirudhan, Varada [2 ]
Du, Ruikun [1 ,3 ,4 ]
Cui, Qinghua [1 ,3 ,4 ]
Rong, Lijun [2 ]
机构：
[1] Shandong Univ Tradit Chinese Med, Coll Pharm, Jinan 250355, Shandong, Peoples R China
[2] Univ Illinois, Dept Microbiol & Immunol, Chicago, IL 60612 USA
[3] Shandong Prov Collaborat Innovat Ctr Antiviral Tr, Jinan, Peoples R China
[4] Shandong Univ Tradit Chinese Med, Qingdao Acad Chinese Med Sci, Qingdao, Peoples R China
来源：
JOURNAL OF MEDICAL VIROLOGY | 2021年 / 93卷 / 01期
关键词：
coronavirus; COVID-19; drug target; RdRp; SARS-CoV-2; NUCLEOSIDE/NUCLEOTIDE ANALOG INHIBITORS; RESPIRATORY SYNDROME CORONAVIRUS; DE-NOVO INITIATION; SARS-CORONAVIRUS; INFLUENZA-A; EBOLA-VIRUS; ZIKA VIRUS; IN-VITRO; NUCLEOSIDE ANALOGS; INTERFERON-BETA;
D O I：
10.1002/jmv.26264
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The global pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), named coronavirus disease 2019, has infected more than 8.9 million people worldwide. This calls for urgent effective therapeutic measures. RNA-dependent RNA polymerase (RdRp) activity in viral transcription and replication has been recognized as an attractive target to design novel antiviral strategies. Although SARS-CoV-2 shares less genetic similarity with SARS-CoV (similar to 79%) and Middle East respiratory syndrome coronavirus (similar to 50%), the respective RdRps of the three coronaviruses are highly conserved, suggesting that RdRp is a good broad-spectrum antiviral target for coronaviruses. In this review, we discuss the antiviral potential of RdRp inhibitors (mainly nucleoside analogs) with an aim to provide a comprehensive account of drug discovery on SARS-CoV-2.
引用
收藏
页码：300 / 310
页数：11
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