The main protease and RNA-dependent RNA polymerase are two prime targets for SARS-CoV-2

被引：25
|
作者：
Jin, Zhenming [1 ,2 ,3 ]
Wang, Haofeng [1 ,2 ]
Duan, Yinkai [1 ]
Yang, Haitao [1 ]
机构：
[1] ShanghaiTech Univ, Shanghai Inst Adv Immunochem Studies, Shanghai, Peoples R China
[2] Tsinghua Univ, Sch Life Sci, Beijing, Peoples R China
[3] Tsinghua Univ, Sch Med, Beijing, Peoples R China
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2021年 / 538卷
基金：
中国国家自然科学基金;
关键词：
Main protease; RNA-dependent RNA polymerase; SARS-CoV-2; Inhibitors; RESPIRATORY SYNDROME SARS; HUMAN CORONAVIRUS; STRUCTURAL BASIS; INFECTION ETIOLOGY; VIRUS; EPIDEMIOLOGY; REPLICATION; 3C; INHIBITION; PREVENTION;
D O I：
10.1016/j.bbrc.2020.10.091
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), poses an unprecedented global health crisis. It is particularly urgent to develop clinically effective therapies to contain the pandemic. The main protease (M-pro) and the RNA-dependent RNA polymerase (RdRP), which are responsible for the viral polyprotein proteolytic process and viral genome replication and transcription, respectively, are two attractive drug targets for SARS-CoV-2. This review summarizes up-to-date progress in the structural and pharmacological aspects of those two key targets above. Different classes of inhibitors individually targeting M-pro and RdRP are discussed, which could promote drug development to treat SARS-CoV-2 infection. (C) 2020 Elsevier Inc. All rights reserved.
引用
收藏
页码：63 / 71
页数：9
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