Microwave-assisted synthesis of novel 1,3,4-thiadiazolyl-substituted 1,2,4-triazines as potential antitubercular agents

被引：14
|
作者：
Kidwai, M [1 ]
Kumar, R
Srivastava, A
Gupta, HP
机构：
[1] Univ Delhi, Dept Chem, Delhi 110007, India
[2] Cent Drug Res Inst, Dept Microbiol, Lucknow 226001, Uttar Pradesh, India
来源：
BIOORGANIC CHEMISTRY | 1998年 / 26卷 / 05期
关键词：
D O I：
10.1006/bioo.1998.1108
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A series of triazines have been synthesized starting from 5-alkyl-1,3,4-thiadiazole-2-thioles (1a-d). On reaction with ethyl bromoacetate in the presence of anhydrous K2CO3 under microwave irradiation (MWI), these yielded corresponding esters (2a-d) which on hydrazinolysis under MWI produced (5-alkyl-1,3,4-thiadiazol-2-yl sulfanyl) acetohydrazides (3a-d). The reaction of 3a-d with omega-bromoacetophenone under MWI yielded 6-aryl-3-[(5-alkyl-1,3,4-thiadiazo1-2-yl sulfanyl)methyl]-1,2,4-triazines (4a-h). All the synthesized triazines showed bl vitro antitubercular activity, (C) 1998 Academic Press.
引用
收藏
页码：289 / 294
页数：6
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