Genome-Wide Association Analysis Reveals Genetic Loci and Candidate Genes for Chest, Abdominal, and Waist Circumferences in Two Duroc Pig Populations

被引:8
|
作者
Zhou, Shenping [1 ,2 ,3 ]
Ding, Rongrong [2 ,3 ,4 ]
Zhuang, Zhanwei [2 ,3 ]
Zeng, Haiyu [4 ]
Wen, Shuxian [4 ]
Ruan, Donglin [2 ,3 ]
Wu, Jie [2 ,3 ]
Qiu, Yibin [2 ,3 ]
Zheng, Enqin [2 ,3 ]
Cai, Gengyuan [2 ,3 ,4 ]
Yang, Jie [2 ,3 ]
Wu, Zhenfang [2 ,3 ,4 ]
Yang, Ming [1 ]
机构
[1] Zhongkai Univ Agr & Engn, Coll Anim Sci & Technol, Guangzhou, Peoples R China
[2] South China Agr Univ, Coll Anim Sci, Guangzhou, Peoples R China
[3] South China Agr Univ, Natl Engn Res Ctr Breeding Swine Ind, Guangzhou, Peoples R China
[4] Guangdong Wens Breeding Swine Technol Co Ltd, Yunfu, Peoples R China
关键词
single-trait GWAS; Duroc pigs; chest circumference; abdominal circumference; waist circumference; multi-trait GWAS; COMPLEX TRAITS; INTELLIGENCE; CONFORMATION;
D O I
10.3389/fvets.2021.807003
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
Chest circumference (CC), abdominal circumference (AC), and waist circumference (WC) are regarded as important indicators for improving economic traits because they can reflect the growth and physiological status in pigs. However, the genetic architecture of CC, AC, and WC is still elusive. Here, we performed single-trait and multi-trait genome-wide association studies (GWASs) for CC, AC, and WC in 2,206 American origin Duroc (AOD) and 2,082 Canadian origin Duroc (COD) pigs. As a result, one novel quantitative trait locus (QTL) on Sus scrofa chromosome (SSC) one was associated with CC and AC in COD pigs, which spans 6.92 Mb (from 170.06 to 176.98 Mb). Moreover, multi-trait GWAS identified 21 significant SNPs associated with the three conformation traits, indicating the multi-trait GWAS is a powerful statistical approach that uncovers pleiotropic locus. Finally, the three candidate genes (ITGA11, TLE3, and GALC) were selected that may play a role in the conformation traits. Further bioinformatics analysis indicated that the candidate genes for the three conformation traits mainly participated in sphingolipid metabolism and lysosome pathways. For all we know, this study was the first GWAS for WC in pigs. In general, our findings further reveal the genetic architecture of CC, AC, and WC, which may offer a useful reference for improving the conformation traits in pigs.
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页数:11
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