The possible role of glutathione-S-transferase activity in diabetic nephropathy

被引：22
|
作者：
Tesauro, M. [1 ]
Nistico, S. [2 ]
Noce, A. [1 ]
Tarantino, A. [1 ]
Marrone, G. [1 ]
Costa, A. [3 ]
Rovella, V. [1 ]
Di Cola, G. [1 ]
Campia, U. [4 ]
Lauro, D. [5 ]
Cardillo, C. [6 ]
Di Daniele, N. [1 ]
机构：
[1] Univ Roma Tor Vergata, Div Nephrol & Hypertens, Dept Syst Med, Rome, Italy
[2] Univ Catanzaro Magna Graecia, Dept Hlth Sci, Catanzaro, Italy
[3] Campus Biomed Univ Rome, Ctr Integrated Res, Rome, Italy
[4] MedStar Cardiovasc Res Network Washington, Washington, DC USA
[5] Univ Roma Tor Vergata, Endocrinol Unit, Rome, Italy
[6] Catholic Univ, Internal Med, Rome, Italy
来源：
INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY | 2015年 / 28卷 / 01期
关键词：
biomarkers; diabetic nephropathy; glutathione-S-transferase; oxidative stress; TYPE-2; MICROALBUMINURIA; POLYMORPHISMS; EVOLUTION; MELLITUS; VALUES; GSTM1; T1;
D O I：
10.1177/0394632015572564
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The most common cause of end stage renal disease is diabetic nephropathy. An early diagnosis may allow an intervention to slow down disease progression. Recently, it has been hypothesized that glutathione-S-transferase (GST) activity may be a marker of severity of chronic kidney disease. In particular, a lower GST activity is present in healthy subjects compared to patients with nephropathy. In the present review we illustrate the scientific evidence underlying the possible role of GST activity in the development of diabetic nephropathy and we analyze its usefulness as a possible early biomarker of this diabetic complication.
引用
收藏
页码：129 / 133
页数：5
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