Zinc-promoted hydrohydrazination of terminal alkynes: An efficient domino synthesis of indoles

被引：152
|
作者：
Alex, Karolin [1 ]
Tillack, Annegret [1 ]
Schwarz, Nicolle [1 ]
Beller, Matthias [1 ]
机构：
[1] Univ Rostock, Leibniz Inst Katalyse eV, D-18059 Rostock, Germany
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 12期
关键词：
alkynes; hydrohydrazinations; indole; zinc;
D O I：
10.1002/anie.200703823
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Chemical Equation Presented) Indole click chemistry: The quest for better catalysts for the intermolecular hydrohydrazination to indoles leads to zinc salts. A simple one-pot synthesis forms indoles from arylhydrazines and terminal alkynes. The pharmacologically relevant indole building blocks are selectively formed in the presence of zinc triflate (Zn(OTf)2) or ZnCl 2 (see scheme). © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：2304 / 2307
页数：4
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