Zinc-promoted hydrohydrazination of terminal alkynes: An efficient domino synthesis of indoles

被引：152

作者：

Alex, Karolin ^{[1
]}

Tillack, Annegret ^{[1
]}

Schwarz, Nicolle ^{[1
]}

Beller, Matthias ^{[1
]}

机构：

[1] Univ Rostock, Leibniz Inst Katalyse eV, D-18059 Rostock, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 12期

关键词：

alkynes; hydrohydrazinations; indole; zinc;

D O I：

10.1002/anie.200703823

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Indole click chemistry: The quest for better catalysts for the intermolecular hydrohydrazination to indoles leads to zinc salts. A simple one-pot synthesis forms indoles from arylhydrazines and terminal alkynes. The pharmacologically relevant indole building blocks are selectively formed in the presence of zinc triflate (Zn(OTf)2) or ZnCl 2 (see scheme). © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：2304 / 2307

页数：4

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