Novel bioconversion products of andrographolide by Aspergillus ochraceus and their cytotoxic activities against human tumor cell lines

被引：9
|
作者：
He, Xiangjiu [1 ]
Wang, Yihai [1 ]
Hu, Hui [1 ]
Wu, Yixuan [1 ]
Zeng, Xiaobin [1 ]
机构：
[1] Wuhan Univ, Coll Pharm, Wuhan 430071, Peoples R China
来源：
JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC | 2011年 / 68卷 / 01期
关键词：
Andrographolide; Aspergillus ochraceus; Hydroxylation; Microbial conversion; Cytotoxicity; CYCLE ARREST; APOPTOSIS; INTERFERES; PROTECTS; PHASE;
D O I：
10.1016/j.molcatb.2010.09.017
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Andrographolide (1) a major labdane diterpenoidal constituent of a famous traditional Chinese of Andrographis paniculata exhibits a wide spectrum of biological activities including antibacterial, anti-inflammatory and antitumor properties Bioconversion of andrographolide (1) by Aspergillus ochraceus (ATCC 1008) was investigated Five bioconversion products were isolated and identified Their structures were identified to be 8 beta-hydroxy-8(17)-dihydroandrographolide (2), 8 beta-hydroxy-8(17)-dihydro-14-deoxy-11 12-didehydroandrographohde (3) 80-hydroxy-8(17)-dihydro-14-deoxy-11 12-didehydroandrographolide 19-oic acid (4). 14-deoxy-11 12-didehydroandrographolide (5), and 14-deoxy-11 12-didehydroandrographolide 19-oic acid (6) Metabolites 2-4 were novel compounds The proposed biosynthetic pathways of andrographolide by A ochraceus were drawn Most bloconversion products showed potential cytotoxic activities against human breast cancer (MCF-7) human colon cancer (HCT-116) and leukemia (HL-60) cell lines (c) 2010 Elsevier B V All rights reserved
引用
收藏
页码：89 / 93
页数：5
相关论文
共 50 条
  • [31] Flavonoids from Artemisia sacrorum Ledeb. and their cytotoxic activities against human cancer cell lines
    Yuan, Haidan
    Lu, Xuyang
    Ma, Qianqian
    Li, Di
    Xu, Guanghua
    Piao, Guangchun
    EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2016, 12 (03) : 1873 - 1878
  • [32] Cytotoxic and Photocytotoxic Effects of Cercosporin on Human Tumor Cell Lines
    Mastrangelopoulou, Maria
    Grigalavicius, Mantas
    Berg, Kristian
    Menard, Mathilde
    Theodossiou, Theodossis A.
    PHOTOCHEMISTRY AND PHOTOBIOLOGY, 2019, 95 (01) : 387 - 396
  • [33] Annona squamosa Linn: Cytotoxic activity found in leaf extract against human tumor cell lines
    Wang, De-Shen
    Rizwani, Ghazala H.
    Guo, Huiqin
    Ahmed, Mansoor
    Ahmed, Maryam
    Hassan, Syed Zeeshan
    Hassan, Amir
    Chen, Zhe-Sheng
    Xu, Rui-Hua
    PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2014, 27 (05) : 1559 - 1563
  • [34] CYTOTOXIC ACTIVITY OF PARIS QUADRIFOLIA EXTRACT AND ISOLATED SAPONIN FRACTIONS AGAINST HUMAN TUMOR CELL LINES
    Stefanowicz-Hajduk, Justyna
    Kawiak, Anna
    Gajdus, Jerzy
    Ochocka, J. Renata
    Paszkiewicz, Monika
    Stepnowski, Piotr
    Lojkowska, Ewa
    ACTA BIOLOGICA CRACOVIENSIA SERIES BOTANICA, 2011, 53 (02) : 127 - 131
  • [35] Cytotoxic activity of 5-benzoylimidazole and related compounds against human oral tumor cell lines
    Terasawa, K
    Sugita, Y
    Yokoe, I
    Fujisawa, S
    Sakagami, H
    ANTICANCER RESEARCH, 2001, 21 (2A) : 1081 - 1086
  • [36] Novel ruthenium(II) complexes with cimetidine: DFT calculations and in vitro cytotoxic activities against glioblastoma cell lines
    Moreira Dias, Julia Scaff
    Reis Silva, Henrique Vieira
    Candido, Caio Cesar
    Ferreira da Silva, Guilherme Alvaro
    Ionta, Marisa
    Almeida, Fernando
    Viana, Rommel Bezerra
    Frazao Barbosa, Marilia Imaculada
    Doriguetto, Antonio Carlos
    INORGANICA CHIMICA ACTA, 2020, 506
  • [37] EFFECT OF HYPERTHERMIA ON THE CYTOLYTIC ACTIVITIES OF IFNS AGAINST HUMAN CUTANEOUS TUMOR-CELL LINES
    TYRING, SK
    ALBRECHT, C
    BRYSK, M
    FLEISCHMANN, WR
    SAMS, WM
    BARON, S
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1986, 86 (04) : 512 - 512
  • [38] Synthesis of piperine–amino acid ester conjugates and study of their cytotoxic activities against human cancer cell lines
    V. Rama Subba Rao
    G. Suresh
    R. Ranga Rao
    K. Suresh Babu
    G. Chashoo
    A. K. Saxena
    J. Madhusudana Rao
    Medicinal Chemistry Research, 2012, 21 : 38 - 46
  • [39] Cytotoxic activities of Snow Lotus filtrates against human cancer cell lines and origin of active factor(s)
    Badisa, RB
    Badisa, VLD
    Watson, DM
    Pilarinou, E
    Walker, EH
    PHARMACEUTICAL BIOLOGY, 2004, 42 (02) : 117 - 124
  • [40] Synthesis, Characterization, and In Vitro Cytotoxic Activities of Benzaldehyde Thiosemicarbazone Derivatives and Their Palladium (II) and Platinum (II) Complexes against Various Human Tumor Cell Lines
    Hernandeza, Wilfredo
    Paz, Juan
    Vaisberg, Abraham
    Spodine, Evgenia
    Richter, Rainer
    Beyer, Lothar
    BIOINORGANIC CHEMISTRY AND APPLICATIONS, 2008, 2008
12345