Novel bioconversion products of andrographolide by Aspergillus ochraceus and their cytotoxic activities against human tumor cell lines

被引：9

作者：

He, Xiangjiu ^{[1
]}

Wang, Yihai ^{[1
]}

Hu, Hui ^{[1
]}

Wu, Yixuan ^{[1
]}

Zeng, Xiaobin ^{[1
]}

机构：

[1] Wuhan Univ, Coll Pharm, Wuhan 430071, Peoples R China

来源：

JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC | 2011年 / 68卷 / 01期

关键词：

Andrographolide; Aspergillus ochraceus; Hydroxylation; Microbial conversion; Cytotoxicity; CYCLE ARREST; APOPTOSIS; INTERFERES; PROTECTS; PHASE;

D O I：

10.1016/j.molcatb.2010.09.017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Andrographolide (1) a major labdane diterpenoidal constituent of a famous traditional Chinese of Andrographis paniculata exhibits a wide spectrum of biological activities including antibacterial, anti-inflammatory and antitumor properties Bioconversion of andrographolide (1) by Aspergillus ochraceus (ATCC 1008) was investigated Five bioconversion products were isolated and identified Their structures were identified to be 8 beta-hydroxy-8(17)-dihydroandrographolide (2), 8 beta-hydroxy-8(17)-dihydro-14-deoxy-11 12-didehydroandrographohde (3) 80-hydroxy-8(17)-dihydro-14-deoxy-11 12-didehydroandrographolide 19-oic acid (4). 14-deoxy-11 12-didehydroandrographolide (5), and 14-deoxy-11 12-didehydroandrographolide 19-oic acid (6) Metabolites 2-4 were novel compounds The proposed biosynthetic pathways of andrographolide by A ochraceus were drawn Most bloconversion products showed potential cytotoxic activities against human breast cancer (MCF-7) human colon cancer (HCT-116) and leukemia (HL-60) cell lines (c) 2010 Elsevier B V All rights reserved

引用

页码：89 / 93

页数：5

共 50 条

[21] Cytotoxic Activities of Total Saponins from Plena Clematis on Human Tumor Cell Lines In Vitro
ZHU Furong
LI Yongning
HE Shulan
CHEN Qianshun
XU Xunyu
Chinese Journal of Integrative Medicine, 2018, 24 (10) : 763 - 767
[22] Syntheses of novel β-carboline derivatives and the activities against five tumor-cell lines
Bai, Bing
Li, Xing-Yao
Liu, Li
Li, Yan
Zhu, Hua-Jie
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2014, 24 (01) : 96 - 98
[23] SELECTIVE CYTOTOXIC ACTIVITY OF BREFELDIN-A AGAINST HUMAN-TUMOR CELL-LINES
ISHII, S
NAGASAWA, M
KARIYA, Y
YAMAMOTO, H
JOURNAL OF ANTIBIOTICS, 1989, 42 (12): : 1877 - 1878
[24] CYTOTOXIC ACTIVITY OF HUMAN-LYMPHOCYTES AGAINST DIFFERENTIATED INTESTINAL TUMOR-CELL LINES
ANELLI, R
PLACIDO, R
SAMBUY, Y
BACH, S
DIMASSIMO, A
COLIZZI, V
IMMUNOLOGY, 1993, 78 (01) : 166 - 169
[25] Cytotoxic activity of saponins from Camassia leichtlinii against human oral tumor cell lines
Furuya, S
Takayama, F
Mimaki, Y
Sashida, Y
Satoh, K
Sakagami, H
ANTICANCER RESEARCH, 2001, 21 (2A) : 959 - 964
[26] Cytotoxic activity of low molecular weight polyphenols against human oral tumor cell lines
Fukai, T
Sakagami, H
Toguchi, M
Takayama, F
Iwakura, I
Atsumi, T
Ueha, T
Nakashima, H
Nomura, T
ANTICANCER RESEARCH, 2000, 20 (04) : 2525 - 2536
[27] Cytotoxic activity of hydrolyzable tannins against human oral tumor cell lines - A possible mechanism
Sakagami, H
Jiang, Y
Kusama, K
Atsumi, T
Ueha, T
Toguchi, M
Iwakura, I
Satoh, K
Ito, H
Hatano, T
Yoshida, T
PHYTOMEDICINE, 2000, 7 (01) : 39 - 47
[28] Pyrimethanil: Between efficient fungicide against Aspergillus rot on cherry tomato and cytotoxic agent on human cell lines
Aleksic, Milena
Stanisavljevic, Danijela
Smiljkovic, Marija
Vasiljevic, Perica
Stevanovic, Milena
Sokovic, Marina
Stojkovic, Dejan
ANNALS OF APPLIED BIOLOGY, 2019, 175 (02) : 228 - 235
[29] Cytotoxic and Apoptosis-Inducing Activities of Steviol and Isosteviol Derivatives against Human Cancer Cell Lines
Ukiya, Motohiko
Sawada, Shingo
Kikuchi, Takashi
Kushi, Yasunori
Fukatsu, Makoto
Akihisa, Toshihiro
CHEMISTRY & BIODIVERSITY, 2013, 10 (02) : 177 - 188
[30] Cytotoxic activities of Padina gymnospora and Acanthophora spicifera extracts against human breast cancer cell lines
Salamat, N.
Derakhshesh, N.
Shiry, N.
Alavinia, S. J.
IRANIAN JOURNAL OF FISHERIES SCIENCES, 2022, 21 (06): : 1527 - 1538

← 1 2 3 4 5 →