Novel bioconversion products of andrographolide by Aspergillus ochraceus and their cytotoxic activities against human tumor cell lines

被引：9
|
作者：
He, Xiangjiu [1 ]
Wang, Yihai [1 ]
Hu, Hui [1 ]
Wu, Yixuan [1 ]
Zeng, Xiaobin [1 ]
机构：
[1] Wuhan Univ, Coll Pharm, Wuhan 430071, Peoples R China
来源：
JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC | 2011年 / 68卷 / 01期
关键词：
Andrographolide; Aspergillus ochraceus; Hydroxylation; Microbial conversion; Cytotoxicity; CYCLE ARREST; APOPTOSIS; INTERFERES; PROTECTS; PHASE;
D O I：
10.1016/j.molcatb.2010.09.017
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Andrographolide (1) a major labdane diterpenoidal constituent of a famous traditional Chinese of Andrographis paniculata exhibits a wide spectrum of biological activities including antibacterial, anti-inflammatory and antitumor properties Bioconversion of andrographolide (1) by Aspergillus ochraceus (ATCC 1008) was investigated Five bioconversion products were isolated and identified Their structures were identified to be 8 beta-hydroxy-8(17)-dihydroandrographolide (2), 8 beta-hydroxy-8(17)-dihydro-14-deoxy-11 12-didehydroandrographohde (3) 80-hydroxy-8(17)-dihydro-14-deoxy-11 12-didehydroandrographolide 19-oic acid (4). 14-deoxy-11 12-didehydroandrographolide (5), and 14-deoxy-11 12-didehydroandrographolide 19-oic acid (6) Metabolites 2-4 were novel compounds The proposed biosynthetic pathways of andrographolide by A ochraceus were drawn Most bloconversion products showed potential cytotoxic activities against human breast cancer (MCF-7) human colon cancer (HCT-116) and leukemia (HL-60) cell lines (c) 2010 Elsevier B V All rights reserved
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页码：89 / 93
页数：5
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