Nonsense-mediated mRNA decay

被引：45
|
作者：
Wen, Jikai [1 ]
Brogna, Saverio [1 ]
机构：
[1] Univ Birmingham, Sch Biosci, Birmingham B15 2TT, W Midlands, England
来源：
BIOCHEMICAL SOCIETY TRANSACTIONS | 2008年 / 36卷
关键词：
exon-exon junction complex (EJC); intron; nonsense-mediated mRNA decay (NMD); nuclear translation; splicing; translation;
D O I：
10.1042/BST0360514
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Translation and mRNA decay are coupled processes; the link is most obvious in the case of NMD (nonsense-mediated mRNA decay). NMD is a mechanism that drastically reduces the level of mRNA harbouring PTCs (premature translation termination codons). The defining event in NMD is premature translation termination and the key question is: what distinguishes premature from normal translation termination? Surprisingly, in mammalian cells, PTC recognition is linked to pre-mRNA splicing. Here, we review the Current understanding in view of recent developments.
引用
收藏
页码：514 / 516
页数：3
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