Nonsense-mediated mRNA decay

被引：45

作者：

Wen, Jikai ^{[1
]}

Brogna, Saverio ^{[1
]}

机构：

[1] Univ Birmingham, Sch Biosci, Birmingham B15 2TT, W Midlands, England

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2008年 / 36卷

关键词：

exon-exon junction complex (EJC); intron; nonsense-mediated mRNA decay (NMD); nuclear translation; splicing; translation;

D O I：

10.1042/BST0360514

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Translation and mRNA decay are coupled processes; the link is most obvious in the case of NMD (nonsense-mediated mRNA decay). NMD is a mechanism that drastically reduces the level of mRNA harbouring PTCs (premature translation termination codons). The defining event in NMD is premature translation termination and the key question is: what distinguishes premature from normal translation termination? Surprisingly, in mammalian cells, PTC recognition is linked to pre-mRNA splicing. Here, we review the Current understanding in view of recent developments.

引用

页码：514 / 516

页数：3

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