Electrochemical Synthesis of α-Ketoamides under Catalyst-, Oxidant-, and Electrolyte-Free Conditions

被引:47
|
作者
Chen, Jin-Yang [1 ]
Wu, Hong-Yu [1 ]
Gui, Qing-Wen [2 ,3 ]
Han, Xiao-Ran [1 ]
Wu, Yan [1 ]
Du, Kui [1 ]
Cao, Zhong [3 ]
Lin, Ying-Wu [4 ]
He, Wei-Min [3 ]
机构
[1] Yangtze Normal Univ, Coll Chem & Chem Engn, Chongqing 408000, Peoples R China
[2] Hunan Univ Sci & Technol, Sch Chem & Chem Engn, Xiangtan 411201, Peoples R China
[3] Changsha Univ Sci & Technol, Hunan Prov Key Lab Mat Protect Elect Power & Tran, Changsha 410114, Peoples R China
[4] Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China
基金
中国国家自然科学基金;
关键词
C-H FUNCTIONALIZATION; OXIDATIVE AMIDATION; OXOCARBOXYLIC ACIDS; EFFICIENT SYNTHESIS; METAL; ALKYNES; ACCESS; AMINES; ACYLATION; ALDEHYDES;
D O I
10.1021/acs.orglett.0c00387
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A catalyst-, oxidant-, electrolyte-free method for the preparation of alpha-ketoamides through the direct electrochemical amidation of alpha-ketoaldehydes and amines with innocuous hydrogen as the sole byproduct at ambient temperature was developed. The present reaction features clean and mild conditions, excellent functional-group tolerance, and high atom economy and scalability, enabling facile applications in pharmaceutical chemistry.
引用
收藏
页码:2206 / 2209
页数:4
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