Electrochemical Synthesis of α-Ketoamides under Catalyst-, Oxidant-, and Electrolyte-Free Conditions

被引：47

作者：

Chen, Jin-Yang ^{[1
]}

Wu, Hong-Yu ^{[1
]}

Gui, Qing-Wen ^{[2
,3
]}

Han, Xiao-Ran ^{[1
]}

Wu, Yan ^{[1
]}

Du, Kui ^{[1
]}

Cao, Zhong ^{[3
]}

Lin, Ying-Wu ^{[4
]}

He, Wei-Min ^{[3
]}

机构：

[1] Yangtze Normal Univ, Coll Chem & Chem Engn, Chongqing 408000, Peoples R China

[2] Hunan Univ Sci & Technol, Sch Chem & Chem Engn, Xiangtan 411201, Peoples R China

[3] Changsha Univ Sci & Technol, Hunan Prov Key Lab Mat Protect Elect Power & Tran, Changsha 410114, Peoples R China

[4] Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China

来源：

ORGANIC LETTERS | 2020年 / 22卷 / 06期

基金：

中国国家自然科学基金;

关键词：

C-H FUNCTIONALIZATION; OXIDATIVE AMIDATION; OXOCARBOXYLIC ACIDS; EFFICIENT SYNTHESIS; METAL; ALKYNES; ACCESS; AMINES; ACYLATION; ALDEHYDES;

D O I：

10.1021/acs.orglett.0c00387

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A catalyst-, oxidant-, electrolyte-free method for the preparation of alpha-ketoamides through the direct electrochemical amidation of alpha-ketoaldehydes and amines with innocuous hydrogen as the sole byproduct at ambient temperature was developed. The present reaction features clean and mild conditions, excellent functional-group tolerance, and high atom economy and scalability, enabling facile applications in pharmaceutical chemistry.

引用

页码：2206 / 2209

页数：4

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