Fine Control of In Vivo Magnetic Hyperthermia Using Iron Oxide Nanoparticles with Different Coatings and Degree of Aggregation

被引：12
|
作者：
Luengo, Yurena [1 ]
Diaz-Riascos, Zamira V. [2 ,3 ,4 ]
Garcia-Soriano, David [1 ]
Teran, Francisco J. [1 ,5 ,6 ]
Artes-Ibanez, Emilio J. [1 ]
Ibarrola, Oihane [7 ]
Somoza, Alvaro [1 ,5 ,6 ]
Miranda, Rodolfo [1 ,5 ,6 ]
Schwartz, Simo, Jr. [2 ,4 ]
Abasolo, Ibane [2 ,3 ,4 ]
Salas, Gorka [1 ,5 ,6 ]
机构：
[1] Campus Univ Cantoblanco, IMDEA Nanociencia, Madrid 28049, Spain
[2] Univ Autonoma Barcelona, Vall Hebron Inst Recerca VHIR, Drug Delivery & Targeting, Barcelona 08035, Spain
[3] Univ Autonoma Barcelona, Vall Hebron Inst Recerca VHIR, Funct Validat & Preclin Res, Barcelona 08035, Spain
[4] CIBER Bioingn, Biomat & Nanomed CIBER BBN, Monforte Lemos 3-5, Madrid 28029, Spain
[5] CSIC, Unidad Asociada Nanobiotecnol, CNB, Madrid 28049, Spain
[6] IMDEA Nanociencia, Madrid 28049, Spain
[7] Biokeralty Res Inst AIE, Arkaute 5, Vitoria 01510, Spain
来源：
PHARMACEUTICS | 2022年 / 14卷 / 08期
关键词：
magnetic hyperthermia; cancer; nanoparticles; controlled heat in vivo; EFFICIENCY; TRANSLATION;
D O I：
10.3390/pharmaceutics14081526
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The clinical implementation of magnetic hyperthermia has experienced little progress since the first clinical trial was completed in 2005. Some of the hurdles to overcome are the reliable production of magnetic nanoparticles with controlled properties and the control of the temperature at the target tissue in vivo. Here, forty samples of iron oxide superparamagnetic nanoparticles were prepared by similar methods and thoroughly characterized in terms of size, aggregation degree, and heating response. Selected samples were intratumorally administered in animals with subcutaneous xenografts of human pancreatic cancer. In vivo experiments showed that it is possible to control the rise in temperature by modulating the field intensity during in vivo magnetic hyperthermia protocols. The procedure does not require sophisticated materials and it can be easily implemented by researchers or practitioners working in magnetic hyperthermia therapies.
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页数：15
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