Solid-state characterization and solubility enhancement of apremilast drug-drug cocrystals

被引：41
|
作者：
Wang, Feng-Yuan [1 ,2 ]
Zhang, Qi [1 ]
Zhang, Zaiyong [1 ]
Gong, Xiaoyi [1 ]
Wang, Jian-Rong [1 ]
Mei, Xuefeng [1 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Mat Med, Pharmaceut Analyt & Solid State Chem Res Ctr, Shanghai 201203, Peoples R China
[2] Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China
来源：
CRYSTENGCOMM | 2018年 / 20卷 / 39期
关键词：
PHARMACEUTICAL COCRYSTALS; CO-CRYSTALS;
D O I：
10.1039/c8ce00689j
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Three isostructural cocrystals of apremilast, a novel anti-psoriasis oral agent, with nicotinamide, caffeine, and acetylsalicylic acid were successfully designed and synthesized. Both the apparent solubility and intrinsic dissolution rate of apremilast in a pH 2.0 buffer have been improved via the formation of cocrystals.
引用
收藏
页码：5945 / 5948
页数：4
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