Solid-state characterization and solubility enhancement of apremilast drug-drug cocrystals

被引：41
|
作者：
Wang, Feng-Yuan [1 ,2 ]
Zhang, Qi [1 ]
Zhang, Zaiyong [1 ]
Gong, Xiaoyi [1 ]
Wang, Jian-Rong [1 ]
Mei, Xuefeng [1 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Mat Med, Pharmaceut Analyt & Solid State Chem Res Ctr, Shanghai 201203, Peoples R China
[2] Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China
来源：
CRYSTENGCOMM | 2018年 / 20卷 / 39期
关键词：
PHARMACEUTICAL COCRYSTALS; CO-CRYSTALS;
D O I：
10.1039/c8ce00689j
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Three isostructural cocrystals of apremilast, a novel anti-psoriasis oral agent, with nicotinamide, caffeine, and acetylsalicylic acid were successfully designed and synthesized. Both the apparent solubility and intrinsic dissolution rate of apremilast in a pH 2.0 buffer have been improved via the formation of cocrystals.
引用
收藏
页码：5945 / 5948
页数：4
相关论文
共 50 条
  • [31] In Silico Screening as a Tool to Prepare Drug-Drug Cocrystals of Ibrutinib-Ketoconazole: a Strategy to Enhance Their Solubility Profiles and Oral Bioavailability
    Divya Dhatri Kara
    Pragathi Devanand Bangera
    Chetan Hasmukh Mehta
    Katikala Tanvi
    Mahalaxmi Rathnanand
    AAPS PharmSciTech, 24
  • [32] Solid-state chemistry in drug development
    Cains, Peter W.
    CHIMICA OGGI-CHEMISTRY TODAY, 2007, 25 (01) : 12 - +
  • [33] In Silico Screening as a Tool to Prepare Drug-Drug Cocrystals of Ibrutinib-Ketoconazole: a Strategy to Enhance Their Solubility Profiles and Oral Bioavailability
    Kara, Divya Dhatri
    Bangera, Pragathi Devanand
    Mehta, Chetan Hasmukh
    Tanvi, Katikala
    Rathnanand, Mahalaxmi
    AAPS PHARMSCITECH, 2023, 24 (06)
  • [34] Enhanced NSAIDs Solubility in Drug-Drug Formulations with Ciprofloxacin
    Acebedo-Martinez, Francisco Javier
    Dominguez-Martin, Alicia
    Alarcon-Payer, Carolina
    Sevillano-Paez, Alejandro
    Verdugo-Escamilla, Cristobal
    Gonzalez-Perez, Josefa Maria
    Martinez-Checa, Fernando
    Choquesillo-Lazarte, Duane
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (04)
  • [35] The solid-state continuum: a perspective on the interrelationships between different solid-state forms in drug substance and drug product
    Elder, David P.
    Patterson, James E.
    Holm, Rene
    JOURNAL OF PHARMACY AND PHARMACOLOGY, 2015, 67 (06) : 757 - 772
  • [36] Gefitinib salts/cocrystals with phenolic acids as a promising solid-state approach to improve solubility
    Zou, Yao
    Meng, Xin
    Zhang, Baoxi
    Yu, Hongmei
    He, Guorong
    Gong, Ningbo
    Lu, Yang
    Du, Guanhua
    CRYSTENGCOMM, 2024, 26 (15) : 2112 - 2122
  • [37] New Solid Forms of the Anti-HIV Drug Etravirine: Salts, Cocrystals, and Solubility
    Rajput, Lalit
    Sanphui, Palash
    Desiraju, Gautam R.
    CRYSTAL GROWTH & DESIGN, 2013, 13 (08) : 3681 - 3690
  • [38] Polymers for the enhancement of solubility of pharmaceutical substances in solid drug formulations
    D. V. Yudina
    E. V. Blynskaja
    K. V. Alekseev
    A. I. Marakhova
    Russian Chemical Bulletin, 2018, 67 : 787 - 791
  • [39] Polymers for the enhancement of solubility of pharmaceutical substances in solid drug formulations
    Yudina, D. V.
    Blynskaja, E. V.
    Alekseev, K. V.
    Marakhova, A. I.
    RUSSIAN CHEMICAL BULLETIN, 2018, 67 (05) : 787 - 791
  • [40] SOLID DISPERSIONS: A REVIEW ON DRUG DELIVERY SYSTEM AND SOLUBILITY ENHANCEMENT
    Allawadi, Dharna
    Singh, Neelam
    Singh, Sukhbir
    Arora, Sandeep
    INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH, 2013, 4 (06): : 2094 - 2105
12345