Novel isocyanide-based four-component reaction: A facile synthesis of fully substituted 3,4-dihydrocoumarin derivatives

被引：89

作者：

Shaabani, Ahmad ^{[1
]}

Soleimani, Ebrahim ^{[1
]}

Rezayan, Ali Hossein ^{[1
]}

Sarvary, Afshin ^{[1
]}

Khavasi, Hamid Reza ^{[1
]}

机构：

[1] Shahid Beheshti Univ Med Sci, Dept Chem, Tehran, Iran

来源：

ORGANIC LETTERS | 2008年 / 10卷 / 12期

关键词：

D O I：

10.1021/ol800856e

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel isocyanide-based four-component reaction between a 2-hydroxybenzaldehyde, Meldrum's acid, an isocyanide, and an aromatic or an aliphatic alcohol efficiently provide 3,4-dihydrocoumarin derivatives in good to excellent yields without using any catalyst or activation. The reaction can be carried out as a simple one-pot protocol at room temperature.

引用

页码：2581 / 2584

页数：4

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