Novel isocyanide-based four-component reaction: A facile synthesis of fully substituted 3,4-dihydrocoumarin derivatives

被引:89
|
作者
Shaabani, Ahmad [1 ]
Soleimani, Ebrahim [1 ]
Rezayan, Ali Hossein [1 ]
Sarvary, Afshin [1 ]
Khavasi, Hamid Reza [1 ]
机构
[1] Shahid Beheshti Univ Med Sci, Dept Chem, Tehran, Iran
关键词
D O I
10.1021/ol800856e
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A novel isocyanide-based four-component reaction between a 2-hydroxybenzaldehyde, Meldrum's acid, an isocyanide, and an aromatic or an aliphatic alcohol efficiently provide 3,4-dihydrocoumarin derivatives in good to excellent yields without using any catalyst or activation. The reaction can be carried out as a simple one-pot protocol at room temperature.
引用
收藏
页码:2581 / 2584
页数:4
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