Hepatotoxicity after a short course of low-dose pyrazinamide

被引：0
|
作者：
AlSarraf, KAA [1 ]
Michielsen, PP [1 ]
Hauben, EI [1 ]
Lefebure, A [1 ]
Ramon, AM [1 ]
VanMarck, EA [1 ]
Pelckmans, PA [1 ]
机构：
[1] UNIV INSTELLING ANTWERP, FAC MED, DIV GASTROENTEROL, B-2610 ANTWERP, BELGIUM
来源：
ACTA GASTRO-ENTEROLOGICA BELGICA | 1996年 / 59卷 / 04期
关键词：
pyrazinamide; tuberculosis; hepatotoxicity;
D O I：
暂无
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
We report on a patient who developed extensive centrolobular liver necrosis after a treatment with low-dose (25 mg/kg/d) pyrazinamide for only 4 weeks, combined with rifampicin, 600 mg/d), In the past, the patient already developed severe aminotransferase elevations under isoniazid treatment. After prompt withdrawal of the drugs, a gradual decline of the aminotransferases was observed. No signs of hepatic failure developed, Pyrazinamide has to be used with caution, even in low-dose, especially when combined with rifampicin.
引用
收藏
页码：251 / 253
页数：3
相关论文
共 50 条
  • [31] Low-dose, short course cyclosporine as a single agent for prevention of GVHD in patients with advanced leukemia.
    Copelan, E
    Penza, S
    Ezzone, S
    Elder, P
    Hehmeyer, D
    Bechtel, T
    Avalos, B
    BLOOD, 1997, 90 (10) : 3759 - 3759
  • [32] TREATMENT OF CANDIDOSIS IN SEVERELY INJURED ADULTS WITH SHORT-COURSE, LOW-DOSE AMPHOTERICIN-B
    ROSEMURGY, AS
    DROST, TF
    MURPHY, CG
    KEARNEY, RE
    ALBRINK, MH
    JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE, 1990, 30 (12): : 1521 - 1523
  • [33] Experience of Low-Dose, Short-Course Palliative Radiotherapy for Bleeding from Unresectable Gastric Cancer
    Kawabata, Hideaki
    Uno, Koji
    Yasuda, Kenjiro
    Yamashita, Masato
    JOURNAL OF PALLIATIVE MEDICINE, 2017, 20 (02) : 177 - 180
  • [34] METABOLISM TIME-COURSE OF MONOAMINES IN RAT-BRAIN AFTER LOW-DOSE OF CLONIDINE
    KAREGE, F
    GAILLARD, JM
    BIOGENIC AMINES, 1990, 7 (01) : 37 - 48
  • [35] Long course of low-dose dexamethasone following or after bleomycin administration ameliorates pulmonary fibrosis
    Lu, Yifei
    Zhang, Yihan
    Xu, Dengfeng
    Wang, Yuanyuan
    Pan, Da
    Xia, Hui
    Sun, Guiju
    INTERNATIONAL IMMUNOPHARMACOLOGY, 2022, 113
  • [36] Hepatotoxicity Associated with a Short Course of Rosuvastatin
    Hwang, Na Kyoung
    Park, Jin Sup
    Cha, Kwang Soo
    Kang, Jin Suk
    CHINESE MEDICAL JOURNAL, 2015, 128 (12) : 1693 - 1694
  • [37] Hepatotoxicity Associated with a Short Course of Rosuvastatin
    Hwang Na Kyoung
    Park Jin Sup
    Cha Kwang Soo
    Kang Jin Suk
    中华医学杂志英文版, 2015, 128 (12) : 1693 - 1694
  • [38] Low-Dose Colchicine after Myocardial Infarction
    Reindl, Martin
    Metzler, Bernhard
    Reinstadler, Sebastian J.
    NEW ENGLAND JOURNAL OF MEDICINE, 2020, 382 (17): : 1666 - 1668
  • [39] TOXIC DEATH AFTER LOW-DOSE BLEOMYCIN
    ZAMORA, P
    AGUILAR, J
    HERNANDEZ, MA
    SANTANA, C
    MEDICINA CLINICA, 1990, 94 (15): : 597 - 597
  • [40] REVERSAL OF ATRACURIUM AFTER LOW-DOSE TUBOCURARINE
    NOTT, MR
    TANNER, V
    ANAESTHESIA, 1993, 48 (07) : 644 - 644
12345