Hepatotoxicity after a short course of low-dose pyrazinamide

被引：0
|
作者：
AlSarraf, KAA [1 ]
Michielsen, PP [1 ]
Hauben, EI [1 ]
Lefebure, A [1 ]
Ramon, AM [1 ]
VanMarck, EA [1 ]
Pelckmans, PA [1 ]
机构：
[1] UNIV INSTELLING ANTWERP, FAC MED, DIV GASTROENTEROL, B-2610 ANTWERP, BELGIUM
来源：
ACTA GASTRO-ENTEROLOGICA BELGICA | 1996年 / 59卷 / 04期
关键词：
pyrazinamide; tuberculosis; hepatotoxicity;
D O I：
暂无
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
We report on a patient who developed extensive centrolobular liver necrosis after a treatment with low-dose (25 mg/kg/d) pyrazinamide for only 4 weeks, combined with rifampicin, 600 mg/d), In the past, the patient already developed severe aminotransferase elevations under isoniazid treatment. After prompt withdrawal of the drugs, a gradual decline of the aminotransferases was observed. No signs of hepatic failure developed, Pyrazinamide has to be used with caution, even in low-dose, especially when combined with rifampicin.
引用
收藏
页码：251 / 253
页数：3
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