Synthesis and anti-inflammatory activity of steroidal

被引：0
|
作者：
Pathak, D [1 ]
Jindal, DP [1 ]
机构：
[1] Panjab Univ, Inst Pharmaceut Sci, Chandigarh 160014, India
来源：
ASIAN JOURNAL OF CHEMISTRY | 1998年 / 10卷 / 04期
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D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The steroidal isoxazoles, 4-aza-5 alpha-cholestano [3,2-c] isoxazole (2), 4-aza-5 alpha-androstano [3,2-c] isoxazol-17 beta-yl acetate (4) and 17a-aza-D-homo-5-androsteno [17,16-c] isoxazol-3 beta-yl acetate (6) have been prepared and screened for their biological activity. The Compound 2 (ED50 = 5.67 mg/kg), Compound 4 (ED50 = 2.97 mg/kg) and Compound 6 (ED50 = 11.00 mg/kg) were found to be potent anti-inflammatory agents.
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页码：813 / 817
页数：5
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