Synthesis and anti-inflammatory activity of steroidal

被引：0
|
作者：
Pathak, D [1 ]
Jindal, DP [1 ]
机构：
[1] Panjab Univ, Inst Pharmaceut Sci, Chandigarh 160014, India
来源：
ASIAN JOURNAL OF CHEMISTRY | 1998年 / 10卷 / 04期
关键词：
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The steroidal isoxazoles, 4-aza-5 alpha-cholestano [3,2-c] isoxazole (2), 4-aza-5 alpha-androstano [3,2-c] isoxazol-17 beta-yl acetate (4) and 17a-aza-D-homo-5-androsteno [17,16-c] isoxazol-3 beta-yl acetate (6) have been prepared and screened for their biological activity. The Compound 2 (ED50 = 5.67 mg/kg), Compound 4 (ED50 = 2.97 mg/kg) and Compound 6 (ED50 = 11.00 mg/kg) were found to be potent anti-inflammatory agents.
引用
收藏
页码：813 / 817
页数：5
相关论文
共 50 条
  • [21] Anti-inflammatory activity of aqueous extracts and steroidal sapogenins of Agave americana
    Peana, AT
    Moretti, MDL
    Manconi, V
    Desole, G
    Pippia, P
    PLANTA MEDICA, 1997, 63 (03) : 199 - 202
  • [22] INTESTINAL ULCEROGENIC ACTIVITY OF SOME NON STEROIDAL ANTI-INFLAMMATORY AGENTS
    ACHARYA, SB
    RAO, YV
    DEBNATH, PK
    SANYAL, AK
    PHARMACOLOGICAL RESEARCH COMMUNICATIONS, 1981, 13 (02): : 195 - 200
  • [23] Antimicrobial activity of non-steroidal anti-inflammatory drugs.
    Hirji, M
    Greenman, J
    Moran, J
    JOURNAL OF DENTAL RESEARCH, 1996, 75 (05) : 1187 - 1187
  • [24] TISSUE CULTURE FIBROBLAST - A TESTING SYSTEM FOR STEROIDAL ANTI-INFLAMMATORY ACTIVITY
    RUHMANN, AG
    BERLINER, DL
    JOURNAL OF THE RETICULOENDOTHELIAL SOCIETY, 1966, 3 (04): : 380 - &
  • [25] Electrochemical synthesis of precursors of non-steroidal anti-inflammatory agents
    Damodar, J
    Raju, RR
    Reddy, SJ
    INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 2002, 41 (12): : 2655 - 2658
  • [26] SYNTHESIS AND ANTI-INFLAMMATORY ACTIVITY OF STEROIDAL 17-YL-ALPHA-OXOTHIO-CARBOXAMIDES AND RELATED COMPOUNDS
    OBAYASHI, M
    KUZUNA, S
    NOGUCHI, S
    CHEMICAL & PHARMACEUTICAL BULLETIN, 1979, 27 (06) : 1352 - 1359
  • [27] Oxovanadium(IV) complexes of non-steroidal anti-inflammatory drugs: Synthesis, spectroscopy, and antimicrobial activity
    N. Muhammad
    S. Ali
    S. Shahzadi
    A. N. Khan
    Russian Journal of Coordination Chemistry, 2008, 34 : 448 - 453
  • [28] Oxovanadium(IV) complexes of non-steroidal anti-inflammatory drugs: Synthesis, spectroscopy, and antimicrobial activity
    Muhammad, N.
    Ali, S.
    Shahzadi, S.
    Khan, A. N.
    RUSSIAN JOURNAL OF COORDINATION CHEMISTRY, 2008, 34 (06) : 448 - 453
  • [29] Synthesis and anti-inflammatory activity of resveratrol analogs
    Chen, G
    Shan, W
    Wu, YL
    Ren, LX
    Dong, IH
    Ji, ZZ
    CHEMICAL & PHARMACEUTICAL BULLETIN, 2005, 53 (12) : 1587 - 1590
  • [30] Synthesis and anti-inflammatory activity of indole glucosinolates
    Vo, Quan V.
    Trenerry, Craige
    Rochfort, Simone
    Wadeson, Jenny
    Leyton, Carolina
    Hughes, Andrew B.
    BIOORGANIC & MEDICINAL CHEMISTRY, 2014, 22 (02) : 856 - 864
12345