Rational polytherapy in the treatment of acute seizures and status epilepticus

被引：57
|
作者：
Wasterlain, ClaudeG. [1 ,2 ,3 ]
Baldwin, Roger [1 ]
Naylor, David E. [1 ,2 ]
Thompson, Kerry W. [1 ,2 ]
Suchomelova, Lucie [1 ,2 ]
Niquet, Jerome [1 ,2 ]
机构：
[1] VA Greater Angeles Hlth Care Syst, Epilepsy Res Lab, Los Angeles, CA USA
[2] Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurol, Los Angeles, CA 90095 USA
[3] Univ Calif Los Angeles, David Geffen Sch Med, Brain Res Inst, Los Angeles, CA 90095 USA
来源：
EPILEPSIA | 2011年 / 52卷
关键词：
Status epilepticus; Acute seizures; Cholinergic seizures; Drug toxicity; GABA(A) receptors; NMDA receptors; Neuronal injury; Monotherapy; GABA(A) RECEPTORS; TRAFFICKING;
D O I：
10.1111/j.1528-1167.2011.03243.x
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
We used a model of severe cholinergic status epilepticus (SE) to study polytherapy aimed at reversing the effects of seizure-induced loss of synaptic GABA(A) receptors and seizure-induced gain of synaptic NMDA receptors. Combinations of a benzodiazepine with ketamine and valproate, or with ketamine and brivaracetam, were more effective and less toxic than benzodiazepine monotherapy in this model of SE.
引用
收藏
页码：70 / 71
页数：2
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