Rational polytherapy in the treatment of acute seizures and status epilepticus

被引：57

作者：

Wasterlain, ClaudeG. ^{[1
,2
,3
]}

Baldwin, Roger ^{[1
]}

Naylor, David E. ^{[1
,2
]}

Thompson, Kerry W. ^{[1
,2
]}

Suchomelova, Lucie ^{[1
,2
]}

Niquet, Jerome ^{[1
,2
]}

机构：

[1] VA Greater Angeles Hlth Care Syst, Epilepsy Res Lab, Los Angeles, CA USA

[2] Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurol, Los Angeles, CA 90095 USA

[3] Univ Calif Los Angeles, David Geffen Sch Med, Brain Res Inst, Los Angeles, CA 90095 USA

来源：

EPILEPSIA | 2011年 / 52卷

关键词：

Status epilepticus; Acute seizures; Cholinergic seizures; Drug toxicity; GABA(A) receptors; NMDA receptors; Neuronal injury; Monotherapy; GABA(A) RECEPTORS; TRAFFICKING;

D O I：

10.1111/j.1528-1167.2011.03243.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We used a model of severe cholinergic status epilepticus (SE) to study polytherapy aimed at reversing the effects of seizure-induced loss of synaptic GABA(A) receptors and seizure-induced gain of synaptic NMDA receptors. Combinations of a benzodiazepine with ketamine and valproate, or with ketamine and brivaracetam, were more effective and less toxic than benzodiazepine monotherapy in this model of SE.

引用

页码：70 / 71

页数：2

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