Process Development and Scale-Up of AZD7545, a PDK Inhibitor

被引：18

作者：

Patel, Bharti ^{[1
]}

Firkin, Catherine R. ^{[1
]}

Snape, Evan W. ^{[1
]}

Jenkin, Shelley L. ^{[1
]}

Brown, David ^{[1
]}

Chaffey, Julian G. K. ^{[1
]}

Hopes, Philip A. ^{[1
]}

Reens, Carl D. ^{[2
]}

Butters, Mike ^{[1
]}

Moseley, Jonathan D. ^{[1
]}

机构：

[1] AstraZeneca, Avlon Works, Proc Res & Dev, Bristol BS10 7ZE, Avon, England

[2] AstraZeneca, R&D Charnwood, Dev Manufacture, Loughborough LE11 5RH, Leics, England

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2012年 / 16卷 / 03期

关键词：

TREGOE DECISION-ANALYSIS; FACILE SYNTHESIS; ACIDS; TOOL;

D O I：

10.1021/op2003419

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A brief comparison of the early manufacturing routes to AZD7545 is given. Process development of the preferred long-term manufacturing route is reported in detail, and changes from the initial kilogram-scale route are discussed. Scale-up experience from the pilot-plant manufacture is included in the discussion of each stage. Noteworthy aspects throughout the development of AZD7545 concerned chemical hazards, mechanisms, analysis, and impurities, upon which this case study will focus.

引用

页码：447 / 460

页数：14

共 50 条

[31] Abscisic Acid Production: Biotechnology Process Development and Scale-up
Aloisio, Loretta
Lebano, Ilaria
Servo, Emanuela
Spera, Daniela M.
5TH INTERNATIONAL SYMPOSIUM ON INDUSTRIAL BIOTECHNOLOGY (IBIC 2016), 2016, 49 : 133 - 138
[32] DEVELOPMENT AND SCALE-UP OF A PURIFICATION PROCESS FOR AN AVIAN COCCIDIOSIS VACCINE
ADAMS, WR
SHAMIR, A
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1994, 207 : 69 - BTEC
[33] Peptide process development and scale-up to the multikilogram level.
Tolle, JC
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1996, 211 : 21 - IEC
[34] CARBORANES . PROCESS DEVELOPMENT AND SCALE-UP OF 1-ISOPROPENYLCARBORANE
FEIN, MM
PAUSTIAN, JE
INDUSTRIAL & ENGINEERING CHEMISTRY PROCESS DESIGN AND DEVELOPMENT, 1965, 4 (02): : 129 - &
[35] Process Development and Scale-up Comparisons for Transient Production of AAV
Stadelman, Robert
Gillmeister, Michael
Startt, Don
MOLECULAR THERAPY, 2020, 28 (04) : 543 - 543
[36] Development and scale-up of a Fab drug conjugate purification process
Bill, Amber
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2019, 257
[37] Development and scale-up of a high titer cell culture process
Ahuja, Sanjeev
Bui, Thoa
Chen, Jianxin
Chen, John
Dorotheo, Ralph
Jain, Shilpa
Lee, Allison
Russell, Brian
Singh, Shailendra
Qu, Limin
Venkat, Raghavan
Ram, Kripa
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2011, 241
[38] Process Development and Scale-up of the Continuous Flow Nitration of Trifluoromethoxybenzene
Wen, Zhenghui
Jiao, Fengjun
Yang, Mei
Zhao, Shuainan
Zhou, Feng
Chen, Guangwen
ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2017, 21 (11) : 1843 - 1850
[39] Development and Scale-up of a Biocatalytic Process To Form a Chiral Sulfoxide
Goundry, William R. F.
Adams, Bradley
Benson, Helen
Demeritt, Julie
McKown, Steven
Mulholland, Keith
Robertson, Amy
Siedlecki, Paul
Tomlin, Paula
Vare, Kevin
ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2017, 21 (01) : 107 - 113
[40] Development and Scale-Up of an Improved Manufacturing Route to the ATR Inhibitor Ceralasertib
Graham, Mark A.
Askey, Hannah
Campbell, Andrew D.
Chan, Lai
Cooper, Katie G.
Cui, Zhaoshan
Dalgleish, Andrew
Dave, David
Ensor, Gareth
Espinosa, Maria Rita Galan
Hamilton, Peter
Heffernan, Claire
Jackson, Lucinda, V
Jing, Dajiang
Jones, Martin F.
Liu, Pengpeng
Mulholland, Keith R.
Pervez, Mohammed
Popadynec, Michael
Randles, Emma
Tomasi, Simone
Wang, Shenghua
ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2021, 25 (01) : 43 - 56

← 1 2 3 4 5 →