Process Development and Scale-Up of AZD7545, a PDK Inhibitor

被引：18

作者：

Patel, Bharti ^{[1
]}

Firkin, Catherine R. ^{[1
]}

Snape, Evan W. ^{[1
]}

Jenkin, Shelley L. ^{[1
]}

Brown, David ^{[1
]}

Chaffey, Julian G. K. ^{[1
]}

Hopes, Philip A. ^{[1
]}

Reens, Carl D. ^{[2
]}

Butters, Mike ^{[1
]}

Moseley, Jonathan D. ^{[1
]}

机构：

[1] AstraZeneca, Avlon Works, Proc Res & Dev, Bristol BS10 7ZE, Avon, England

[2] AstraZeneca, R&D Charnwood, Dev Manufacture, Loughborough LE11 5RH, Leics, England

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2012年 / 16卷 / 03期

关键词：

TREGOE DECISION-ANALYSIS; FACILE SYNTHESIS; ACIDS; TOOL;

D O I：

10.1021/op2003419

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A brief comparison of the early manufacturing routes to AZD7545 is given. Process development of the preferred long-term manufacturing route is reported in detail, and changes from the initial kilogram-scale route are discussed. Scale-up experience from the pilot-plant manufacture is included in the discussion of each stage. Noteworthy aspects throughout the development of AZD7545 concerned chemical hazards, mechanisms, analysis, and impurities, upon which this case study will focus.

引用

页码：447 / 460

页数：14

共 50 条

[21] Spray Drying of Probiotics: Process Development and Scale-Up
Menshutina, Natalia V.
Gordienko, Maria G.
Voinovskiy, Alexei A.
Zbicinski, Ireneusz
DRYING TECHNOLOGY, 2010, 28 (10) : 1170 - 1177
[22] Regulatory aspects in process development and scale-up of nanopharmaceuticals
Hejmady, Siddhanth
Singhvi, Gautam
Saha, Ranendra Narayan
Dubey, Sunil Kumar
THERAPEUTIC DELIVERY, 2020, 11 (06) : 341 - 343
[23] Process development and scale-up of AG035029
Saenz, James
Mitchell, Mark
Bahmanyar, Sami
Stankovic, Nebojsa
Perry, Michael
Craig-Woods, Bridgette
Kline, Billie
Yu, Shu
Albizati, Kim
ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2007, 11 (01) : 30 - 38
[24] Development and Scale-Up of an Asymmetric Synthesis Process for Alogliptin
Yamada, Masatoshi
Hirano, Sayuri
Tsuruoka, Ryoji
Takasuga, Masahiro
Uno, Kenichi
Yamaguchi, Kotaro
Yamano, Mitsuhisa
Organic Process Research and Development, 2021, 25 (02): : 327 - 336
[25] Development and Scale-Up of an Asymmetric Synthesis Process for Alogliptin
Yamada, Masatoshi
Hirano, Sayuri
Tsuruoka, Ryoji
Takasuga, Masahiro
Uno, Kenichi
Yamaguchi, Kotaro
Yamano, Mitsuhisa
ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2021, 25 (02) : 327 - 336
[26] Process Research and Development of a MTP Inhibitor: Another Case of Disappearing Polymorphs upon Scale-up
Prashad, Mahavir
Sutton, Paul
Wu, Racann
Hu, Bin
Vivelo, James
Carosi, Joseph
Kapa, Prasad
Liang, Jessica
ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2010, 14 (04) : 878 - 882
[27] Process Development and Scale-Up of a Novel Atypical DAT Inhibitor (S)-CE-123
Gonzalez, Eduardo R. Perez
Reck, Bernhard
Kalaba, Predrag
Langer, Thierry
Leban, Johann
Lubec, Gert
ACS OMEGA, 2024, 9 (11): : 12976 - 12983
[28] GUIDELINES FOR PROCESS SCALE-UP
KLINE, PE
VOGEL, AJ
YOUNG, AE
TOWNSEND, DI
MOYER, MP
AERSTIN, FG
CHEMICAL ENGINEERING PROGRESS, 1974, 70 (10) : 67 - 70
[29] SCALE-UP - A PROCESS, NOT A RULE
TATTERSON, G
CHEMICAL PROCESSING, 1994, 57 (05): : 67 - &
[30] Process Development and Scale-up Total Synthesis of Largazole, a Potent Class I Histone Deacetylase Inhibitor
Chen, Qi-Yin
Chaturvedi, Pravin R.
Luesch, Hendrik
ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2018, 22 (02) : 190 - 199

← 1 2 3 4 5 →