Loss of muscarinic M4 receptors in spinal cord of arthritic rats:: implications for a role of M4 receptors in pain response

被引：12
|
作者：
Mulugeta, E
El-Bakri, N
Karlsson, E
Elhassan, A
Adem, A [1 ]
机构：
[1] Karolinska Inst, NEUROTEC, Sect Expt Geriatr, S-14186 Huddinge, Sweden
[2] Huddinge Univ Hosp, Karolinska Inst, Dept Surg Anaesthesiol Radiol & Orthopaed, Div Orthopaed Surg, S-14186 Huddinge, Sweden
[3] United Arab Emirates Univ, Fac Med & Hlth Sci, Dept Pharmacol, Al Ain, U Arab Emirates
来源：
BRAIN RESEARCH | 2003年 / 982卷 / 02期
关键词：
acetylcholine; antinociception; arthritis; analgesia; muscarinic receptor subtype; inflammatory pain;
D O I：
10.1016/S0006-8993(03)03025-7
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Changes in the levels of muscarinic M-4 receptors in spinal cord of acute and chronic arthritic rats (animal models of pain) were studied by receptor autoradiography using muscarinic M-4 receptor subtype selective ligand. Arthritis was induced in female Lewis rats by single intradermal injection of heat-killed Mycobacterium butyricum and sacrificed 12 days (acute group) and 30 days (chronic and control groups) after induction of arthritis. Our results demonstrate significant reduction in the level of M-4 receptors in the spinal cord (Rexed laminae I-X) of acute and chronic arthritic rats compared to controls. These findings suggest that the muscarinic M-4 receptor subtype may be involved in cholinergic mechanisms of analgesia. (C) 2003 Elsevier B.V. All rights reserved.
引用
收藏
页码：284 / 287
页数：4
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