Incidence and Impact of Parvovirus B19 Infection in Seronegative Solid Organ Transplant Recipients

被引:8
|
作者
Rezahosseini, Omid [1 ]
Ekenberg, Christina [2 ]
Moller, Dina Leth [1 ]
Sorensen, Soren Schwartz [3 ,4 ]
Wareham, Neval Ete [2 ]
Perch, Michael [4 ,5 ]
Gustafsson, Finn [4 ,6 ]
Rasmussen, Allan [7 ]
Kirkby, Nikolai [8 ]
Reekie, Joanne [2 ]
Lundgren, Jens [2 ,4 ]
Nielsen, Susanne Dam [1 ,4 ]
机构
[1] Univ Copenhagen, Rigshosp, Dept Infect Dis 8632, Viro Immunol Res Unit, Copenhagen, Denmark
[2] Univ Copenhagen, Rigshosp, Ctr Excellence Ku Hlth Immun & Infect, Dept Infect Dis, Copenhagen, Denmark
[3] Univ Copenhagen, Rigshosp, Dept Nephrol, Copenhagen, Denmark
[4] Univ Copenhagen, Dept Clin Med, Copenhagen, Denmark
[5] Univ Copenhagen, Rigshosp, Dept Cardiol, Sect Lung Transplantat, Copenhagen, Denmark
[6] Univ Copenhagen, Rigshosp, Dept Cardiol, Copenhagen, Denmark
[7] Univ Copenhagen, Rigshosp, Dept Surg Gastroenterol & Transplantat, Copenhagen, Denmark
[8] Univ Copenhagen, Rigshosp, Dept Clin Microbiol, Copenhagen, Denmark
来源
JOURNAL OF INFECTIOUS DISEASES | 2021年 / 224卷 / 05期
基金
新加坡国家研究基金会;
关键词
organ transplant; parvovirus B19; human; polymerase chain reaction; incidence;
D O I
10.1093/infdis/jiab024
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Routine monitoring of parvovirus B19 (B19V) the first 6 months posttransplantation was performed in 241 seronegative solid organ transplant (SOT) recipients. Incidence rates during the first month and the second to sixth months posttransplantation were 1.2 (95% confidence interval [CI], .33-3.2) and 0.21 (95% CI, .06-.57) per 100 recipients per month, respectively. Of the 6 SOT recipients with positive B19V polymerase chain reaction, 3 (50%) were admitted to hospital and 2 (33%) were treated with intravenous immunoglobulin. Thus, routine monitoring of B19V in seronegative SOT recipients may not be necessary. Targeted screening 1 month posttransplantation and screening upon clinical suspicion could be an alternative strategy.
引用
收藏
页码:865 / 869
页数:5
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