Incidence and Impact of Parvovirus B19 Infection in Seronegative Solid Organ Transplant Recipients

被引：8

作者：

Rezahosseini, Omid ^{[1
]}

Ekenberg, Christina ^{[2
]}

Moller, Dina Leth ^{[1
]}

Sorensen, Soren Schwartz ^{[3
,4
]}

Wareham, Neval Ete ^{[2
]}

Perch, Michael ^{[4
,5
]}

Gustafsson, Finn ^{[4
,6
]}

Rasmussen, Allan ^{[7
]}

Kirkby, Nikolai ^{[8
]}

Reekie, Joanne ^{[2
]}

Lundgren, Jens ^{[2
,4
]}

Nielsen, Susanne Dam ^{[1
,4
]}

机构：

[1] Univ Copenhagen, Rigshosp, Dept Infect Dis 8632, Viro Immunol Res Unit, Copenhagen, Denmark

[2] Univ Copenhagen, Rigshosp, Ctr Excellence Ku Hlth Immun & Infect, Dept Infect Dis, Copenhagen, Denmark

[3] Univ Copenhagen, Rigshosp, Dept Nephrol, Copenhagen, Denmark

[4] Univ Copenhagen, Dept Clin Med, Copenhagen, Denmark

[5] Univ Copenhagen, Rigshosp, Dept Cardiol, Sect Lung Transplantat, Copenhagen, Denmark

[6] Univ Copenhagen, Rigshosp, Dept Cardiol, Copenhagen, Denmark

[7] Univ Copenhagen, Rigshosp, Dept Surg Gastroenterol & Transplantat, Copenhagen, Denmark

[8] Univ Copenhagen, Rigshosp, Dept Clin Microbiol, Copenhagen, Denmark

来源：

JOURNAL OF INFECTIOUS DISEASES | 2021年 / 224卷 / 05期

基金：

新加坡国家研究基金会;

关键词：

organ transplant; parvovirus B19; human; polymerase chain reaction; incidence;

D O I：

10.1093/infdis/jiab024

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Routine monitoring of parvovirus B19 (B19V) the first 6 months posttransplantation was performed in 241 seronegative solid organ transplant (SOT) recipients. Incidence rates during the first month and the second to sixth months posttransplantation were 1.2 (95% confidence interval [CI], .33-3.2) and 0.21 (95% CI, .06-.57) per 100 recipients per month, respectively. Of the 6 SOT recipients with positive B19V polymerase chain reaction, 3 (50%) were admitted to hospital and 2 (33%) were treated with intravenous immunoglobulin. Thus, routine monitoring of B19V in seronegative SOT recipients may not be necessary. Targeted screening 1 month posttransplantation and screening upon clinical suspicion could be an alternative strategy.

引用

页码：865 / 869

页数：5

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