Chemical and biological features of Burkholderia cepacia complex lipopolysaccharides

被引：58

作者：

De Soyza, Anthony ^{[1
,2
]}

Silipo, Alba ^{[3
]}

Lanzetta, Rosa ^{[3
]}

Govan, John R. ^{[4
]}

Molinaro, Antonio ^{[3
]}

机构：

[1] Newcastle Univ, Inst Cellular Med, Transplantat & Immunobiol Grp, Newcastle Upon Tyne NE7 7DN, Tyne & Wear, England

[2] Freeman Rd Hosp, Newcastle Upon Tyne NE7 7DN, Tyne & Wear, England

[3] Univ Naples Federico II, Dipartimento Chim Organ & Biochim, Naples, Italy

[4] Royal Infirm, Ctr Infect Dis, Cyst Fibrosis Grp, Edinburgh, Midlothian, Scotland

来源：

INNATE IMMUNITY | 2008年 / 14卷 / 03期

关键词：

cystic fibrosis; Pseudomonas aeruginosa; Burkholderia cenocepacia; lipopolysaccharide; virulence;

D O I：

10.1177/1753425908093984

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Burkholderia cepacia complex comprises 10 closely related Gram-negative organisms all of which appear capable of causing disease in humans. These organisms appear of particular relevance to patients with cystic fibrosis. Lipopolysaccharide (LPS) is an important virulence determinant in Gram-negative pathogens. In this review, we highlight important data within the field commenting on LPS/lipid A structure-to-function relationships and cytokine induction capacity of Burkholderia strains studied so far.

引用

页码：127 / 144

页数：18

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