Transgenic assays for mutations and cancer: current status and future perspectives

被引：24

作者：

Vijg, J

van Steeg, H

机构：

[1] Harvard Univ, Sch Med, Boston, MA 02115 USA

[2] Harvard Univ, Inst Med, Beth Israel Deaconess Med Ctr, Boston, MA 02115 USA

[3] Natl Inst Publ Hlth & Environm, Hlth Effects Res Lab, NL-3720 BA Bilthoven, Netherlands

来源：

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS | 1998年 / 400卷 / 1-2期

关键词：

transgenic mouse model; carcinogenicity; mutagenicity; risk estimation; DNA repair gene; tumor suppressor gene; lacZ; reporter gene;

D O I：

10.1016/S0027-5107(98)00030-X

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Transgenic mouse modelling has proved to be a powerful approach to explore the various steps involved in spontaneous and induced carcinogenesis. Some of the multitude of models currently available have the potential to become a substitute for the expensive, long-term rodent bioassay to predict carcinogenicity of environmental compounds. Here, we review the progress in the development and use of transgenic mouse models specifically for the purpose of carcinogenicity and mutagenicity testing. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：337 / 354

页数：18

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