Transgenic assays for mutations and cancer: current status and future perspectives

被引：24
|
作者：
Vijg, J
van Steeg, H
机构：
[1] Harvard Univ, Sch Med, Boston, MA 02115 USA
[2] Harvard Univ, Inst Med, Beth Israel Deaconess Med Ctr, Boston, MA 02115 USA
[3] Natl Inst Publ Hlth & Environm, Hlth Effects Res Lab, NL-3720 BA Bilthoven, Netherlands
来源：
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS | 1998年 / 400卷 / 1-2期
关键词：
transgenic mouse model; carcinogenicity; mutagenicity; risk estimation; DNA repair gene; tumor suppressor gene; lacZ; reporter gene;
D O I：
10.1016/S0027-5107(98)00030-X
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Transgenic mouse modelling has proved to be a powerful approach to explore the various steps involved in spontaneous and induced carcinogenesis. Some of the multitude of models currently available have the potential to become a substitute for the expensive, long-term rodent bioassay to predict carcinogenicity of environmental compounds. Here, we review the progress in the development and use of transgenic mouse models specifically for the purpose of carcinogenicity and mutagenicity testing. (C) 1998 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：337 / 354
页数：18
相关论文
共 50 条
  • [11] Cancer biomarker discovery: Current status and future perspectives
    Maebert, Katrin
    Cojoc, Monica
    Peitzsch, Claudia
    Kurth, Ina
    Souchelnytskyi, Serhiy
    Dubrovska, Anna
    INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 2014, 90 (08) : 659 - 677
  • [12] Prostate cancer screening: current status and future perspectives
    Strope, Seth A.
    Andriole, Gerald L.
    NATURE REVIEWS UROLOGY, 2010, 7 (09) : 487 - 493
  • [13] Special Issue "Cancer Biomarker: Current Status and Future Perspectives"
    Costantini, Susan
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2025, 26 (05)
  • [14] Radiomics in the Diagnosis of Gastric Cancer: Current Status and Future Perspectives
    Wang, Zhiqiang
    Li, Weiran
    Jin, Di
    Fan, Bing
    CURRENT MEDICAL IMAGING, 2024, 20
  • [15] Current status and future perspectives of ctDNA in head and neck cancer
    Enokida, T.
    ANNALS OF ONCOLOGY, 2024, 35 : S1292 - S1292
  • [16] Current status and future perspectives in biliary tract cancer in Singapore
    Choo, Su Pin
    ANNALS OF ONCOLOGY, 2021, 32 : S244 - S244
  • [17] Current status and future perspectives of immunotherapy in bladder cancer treatment
    Zhangsong Wu
    Jinjian Liu
    Ruixiang Dai
    Song Wu
    Science China(Life Sciences) , 2021, (04) : 512 - 533
  • [18] Current status and future perspectives on neoadjuvant therapy in gastric cancer
    Sheng Ao
    Yuchen Wang
    Qingzhi Song
    Yingjiang Ye
    Guoqing Lyu
    Chinese Journal of Cancer Research, 2021, 33 (02) : 181 - 192
  • [19] Urine biomarkers in bladder cancer - current status and future perspectives
    Maas, Moritz
    Todenhoefer, Tilman
    Black, Peter C.
    NATURE REVIEWS UROLOGY, 2023, 20 (10) : 597 - 614
  • [20] Current status and future perspectives of chemoprevention in head and neck cancer
    Klass, Carmen M.
    Shin, Dong M.
    CURRENT CANCER DRUG TARGETS, 2007, 7 (07) : 623 - 632
12345