New method for the synthesis of nitriles via the O-tert-butyldimethylsilyl aldoximes

被引：14

作者：

Ortiz-Marciales, M ^{[1
]}

Piñero, L ^{[1
]}

Ufret, L ^{[1
]}

Algarín, W ^{[1
]}

Morales, J ^{[1
]}

机构：

[1] Univ Puerto Rico, Dept Chem, Humacao, PR 00791 USA

来源：

SYNTHETIC COMMUNICATIONS | 1998年 / 28卷 / 15期

关键词：

D O I：

10.1080/00397919808004856

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reaction of aromatic aldehyde oximes with TBSCl and imidazole in DMF generates the corresponding O-silylated derivative, which undergoes elimination, affording the nitrile with a high yield. For the fragmentation of the predominantly (E) isomer, a base-catalyzed syn elimination mechanism is proposed.

引用

页码：2807 / 2811

页数：5

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