Direct conversion of aldehydes into nitriles via O-phenylcarbamoylated aldoximes

被引：21
|
作者：
Coskun, N [1 ]
Arikan, N [1 ]
机构：
[1] Uludag Univ, Dept Chem, TR-16059 Bursa, Turkey
来源：
TETRAHEDRON | 1999年 / 55卷 / 40期
关键词：
D O I：
10.1016/S0040-4020(99)00692-4
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
O-Arylcarbamoylated hydroxylamine tosylate reacts with aldehydes at room temperature to give the corresponding O-carbamoylated oximes. The reaction of carbamoylated hydroxylamine with aromatic aldehydes in THF or in toluene at reflux affords the corresponding nitriles and anilinium tosylate in high yield. Attempts to cyclize compounds 2 in the presence of AcCl lead again to the formation of nitriles. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：11943 / 11948
页数：6
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