In-Line Monitoring of Coating Thickness of Pharmaceutical Tablets during Production Scale Film Coating by Terahertz Imaging

被引：0
|
作者：
May, Robert K. [1 ]
Evans, Michael J. [2 ]
Zhong, Shuncong [3 ]
Warr, Ian [4 ]
Gladden, Lynn F. [1 ]
Shen, Yaochun [3 ]
Zeitler, J. Axel [1 ]
机构：
[1] Univ Cambridge, Dept Chem Engn & Biotechnol, Cambridge CB2 3RA, England
[2] TeraView Ltd, Cambridge CB4 0WS, England
[3] Univ Liverpool, Dept Elect & Elect Engn, Liverpool L69 3GJ, Merseyside, England
[4] Oystar Mannesty, Liverpool L34 9JS, Merseyside, England
来源：
35TH INTERNATIONAL CONFERENCE ON INFRARED, MILLIMETER, AND TERAHERTZ WAVES (IRMMW-THZ 2010) | 2010年
关键词：
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中图分类号：
TM [电工技术]; TN [电子技术、通信技术];
学科分类号：
0808 ; 0809 ;
摘要：
We present preliminary results from in-line Terahertz pulsed imaging (TPI) measurements of coating thickness on pharmaceutical tablets made during production-scale film coating. Results of these real-time TPI measurements are compared to those from off-line TPI measurements, as well as weight-gain measurements made on sample tablets removed at discrete time-intervals during production. The results, and their repeatability, demonstrate that real-time monitoring of pharmaceutical tablet coating is not only possible but provides substantially more information than the standard quality control method.
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