Effect of computerised cognitive training on cognitive outcomes in mild cognitive impairment: a systematic review and meta-analysis

被引:124
|
作者
Zhang, Haifeng [1 ,2 ]
Huntley, Jonathan [1 ]
Bhome, Rohan [1 ]
Holmes, Benjamin [1 ]
Cahill, Jack [3 ]
Gould, Rebecca L. [1 ]
Wang, Huali [2 ]
Yu, Xin [2 ]
Howard, Robert [1 ]
机构
[1] UCL, Div Psychiat, London, England
[2] Peking Univ, NHC Key Lab Mental Hlth, Natl Clin Res Ctr Mental Disorders, Inst Mental Hlth,Hosp 6,Beijing Dementia Key Lab, Beijing, Peoples R China
[3] Kings Coll London, Inst Psychiat Psychol & Neurosci, London, England
来源
BMJ OPEN | 2019年 / 9卷 / 08期
关键词
mild cognitive training (MCI); computerised; cognitive training; cognitive outcomes; meta-analysis; OLDER-ADULTS; ALZHEIMERS-DISEASE; RISK; REHABILITATION; INTERVENTIONS; EFFICACY; PROGRAM; INDIVIDUALS; STIMULATION; HEALTHY;
D O I
10.1136/bmjopen-2018-027062
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objectives To determine the effect of computerised cognitive training (CCT) on improving cognitive function for older adults with mild cognitive impairment (MCI). Design Systematic review and meta-analysis. Data sources PubMed, Embase, Web of Science and the Cochrane Library were searched through January 2018. Eligibility criteria Randomised controlled trials comparing CCT with control conditions in those with MCI aged 55+ were included. Data extraction and synthesis Two independent reviewers extracted data and assessed the risk of bias. Effect sizes (Hedges' g and 95% CIs) were calculated and random-effects meta-analyses were performed where three or more studies investigated a comparable intervention and outcome. Heterogeneity was quantified using the I-2 statistic. Results 18 studies met the inclusion criteria and were included in the analyses, involving 690 participants. Meta-analysis revealed small to moderate positive treatment effects compared with control interventions in four domains as follows: global cognitive function (g=0.23, 95%CI 0.03 to 0.44), memory (g=0.30, 95%CI 0.11 to 0.50), working memory (g=0.39, 95%CI 0.12 to 0.66) and executive function (g=0.20, 95%CI -0.03 to 0.43). Statistical significance was reached in all domains apart from executive function. Conclusions This meta-analysis provides evidence that CCT improves cognitive function in older people with MCI. However, the long-term transfer of these improvements and the potential to reduce dementia prevalence remains unknown. Various methodological issues such as heterogeneity in outcome measures, interventions and MCI symptoms and lack of intention-to-treat analyses limit the quality of the literature and represent areas for future research.
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页数:10
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