Nematicidal Stemona Alkaloids from Stemona parviflora

被引：48
|
作者：
Huang, Sheng-Zhuo [1 ]
Kong, Fan-Dong [1 ]
Ma, Qing-Yun [1 ]
Guo, Zhi-Kai [1 ]
Zhou, Li-Man [1 ]
Wang, Qi [1 ]
Dai, Hao-Fu [1 ]
Zhao, You-Xing [1 ]
机构：
[1] Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Key Lab Biol & Genet Resources Trop Crops, Minist Agr, Haikou 571101, Peoples R China
来源：
JOURNAL OF NATURAL PRODUCTS | 2016年 / 79卷 / 10期
关键词：
STEMOFOLINE ALKALOIDS; CRYSTAL-STRUCTURE; JAPONICA; SESSILIFOLIA; SKELETON; ROOTS;
D O I：
10.1021/acs.jnatprod.6b00528
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Eight new alkaloids, 3 beta-n-butylstemonamine (1), 8-oxo-3 beta-n-butylstemonamine (2), 3-n-butylneostemonine (3), 10-epi-3-n-butylneostemonine (4), 8-oxo-oxymaistemonine (5) protostemonine N-4-oxide (6), (19S)-hydroxy-21-methoxystemofoline (7), and parvistemonine A (8), were isolated from the roots of Stemona parviflora, together with 17 known alkaloids. The structures of the new alkaloids were elucidated based on a comprehensive spectroscopic data analysis. The absolute configurations of 1-4 were determined by the ECD exciton chirality method and quantum ECD calculations. Protostemonine (10) and stemofoline (12) showed strong nematicidal activity against Panagrellus redivevus, with IC50 values of 0.10 and 0.46 mu M, respectively.
引用
收藏
页码：2599 / 2605
页数：7
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