Nematicidal Stemona Alkaloids from Stemona parviflora

被引：48

作者：

Huang, Sheng-Zhuo ^{[1
]}

Kong, Fan-Dong ^{[1
]}

Ma, Qing-Yun ^{[1
]}

Guo, Zhi-Kai ^{[1
]}

Zhou, Li-Man ^{[1
]}

Wang, Qi ^{[1
]}

Dai, Hao-Fu ^{[1
]}

Zhao, You-Xing ^{[1
]}

机构：

[1] Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Key Lab Biol & Genet Resources Trop Crops, Minist Agr, Haikou 571101, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2016年 / 79卷 / 10期

关键词：

STEMOFOLINE ALKALOIDS; CRYSTAL-STRUCTURE; JAPONICA; SESSILIFOLIA; SKELETON; ROOTS;

D O I：

10.1021/acs.jnatprod.6b00528

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Eight new alkaloids, 3 beta-n-butylstemonamine (1), 8-oxo-3 beta-n-butylstemonamine (2), 3-n-butylneostemonine (3), 10-epi-3-n-butylneostemonine (4), 8-oxo-oxymaistemonine (5) protostemonine N-4-oxide (6), (19S)-hydroxy-21-methoxystemofoline (7), and parvistemonine A (8), were isolated from the roots of Stemona parviflora, together with 17 known alkaloids. The structures of the new alkaloids were elucidated based on a comprehensive spectroscopic data analysis. The absolute configurations of 1-4 were determined by the ECD exciton chirality method and quantum ECD calculations. Protostemonine (10) and stemofoline (12) showed strong nematicidal activity against Panagrellus redivevus, with IC50 values of 0.10 and 0.46 mu M, respectively.

引用

页码：2599 / 2605

页数：7

共 50 条

[21] Search for Snail Repellents: Antimollusc Activities from Stemona parviflora and Six Other Chinese Stemona Species
Teng, Hui-dan
Tan, Cheng-yong
He, Yan-ni
Cai, Xiang-hai
Chen, Gao
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2024, 72 (12) : 6203 - 6212
[22] ALKALOIDS OF STEMONA SESSILIFOLIA
EDWARDS, OE
HANDA, KL
FENIAK, G
CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, 1962, 40 (03): : 455 - &
[23] Absolute Structures of Stemona-Lactam S and Tuberostemospiroline, Alkaloids from Stemona tuberosa
Fukaya, Haruhiko
Hitotsuyanagi, Yukio
Aoyagi, Yutaka
Shu, Zhu
Komatsu, Katsuko
Takeya, Koichi
CHEMICAL & PHARMACEUTICAL BULLETIN, 2013, 61 (10) : 1085 - 1089
[24] New Stemona alkaloids from the roots of Stemona tuberosa and structural revision of stemonatuberone B
Shi, Ze-Hui
Zhou, Zhong-Bo
Qin, Wan-Ning
Wei, Jing-Jing
Xie, Sai-Sai
Jiang, Jia-Meng
Xia, Dan
Pan, Ke
TETRAHEDRON LETTERS, 2020, 61 (22)
[25] Alkaloids from the Roots of Stemona aphylla
Mungkornasawakul, Pitchaya
Chaiyong, Sukanda
Sastraruji, Thanapat
Jatisatienr, Araya
Jatisatienr, Chaiwat
Pyne, Stephen G.
Ung, Alison T.
Korth, John
Lie, Wilford
JOURNAL OF NATURAL PRODUCTS, 2009, 72 (05): : 848 - 851
[26] Novel alkaloids from Stemona sessilifolia
Qian, Jie
Zhan, Zha-Jun
HELVETICA CHIMICA ACTA, 2007, 90 (02) : 326 - 331
[27] Structures and bioactivity of alkaloids from Stemona
Ye, Y.
Lin, L.
Tong, C.
Lin, G.
Velten, R.
PLANTA MEDICA, 2007, 73 (09) : 800 - 800
[28] Bisbenzopyrans and alkaloids from the roots of Stemona cochinchinensis
Dien, Pham-Huu
Lin, Li-Gin
Tang, Chun-Ping
Ke, Chang-Qiang
Ye, Yang
NATURAL PRODUCT RESEARCH, 2008, 22 (10) : 915 - 920
[29] Stemona-amines C-E, new alkaloids from Stemona tuberosa
Hitotsuyanagi, Yukio
Shigemori, Genta
Fukaya, Haruhiko
Hikita, Maho
Zhu, Shu
Komatsu, Katsuko
Takeya, Koichi
TETRAHEDRON LETTERS, 2013, 54 (51) : 6995 - 6998
[30] A synthetic approach to the Stemona alkaloids
Hinman, MM
Heathcock, CH
JOURNAL OF ORGANIC CHEMISTRY, 2001, 66 (23): : 7751 - 7756

← 1 2 3 4 5 →