Protein kinase Cθ:: a new essential superstar on the T-cell stage

被引：134
|
作者：
Altman, A
Isakov, N
Baier, G
机构：
[1] La Jolla Inst Allergy & Immunol, Div Cell Biol, San Diego, CA 92121 USA
[2] Ben Gurion Univ Negev, Dept Microbiol & Immunol, IL-84105 Beer Sheva, Israel
[3] Univ Innsbruck, Inst Med Biol & Human Genet, A-6020 Innsbruck, Austria
来源：
IMMUNOLOGY TODAY | 2000年 / 21卷 / 11期
关键词：
D O I：
10.1016/S0167-5699(00)01749-7
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Recent studies have identified protein kinase C theta (PKC theta), a member of the Ca2+-independent PKC family as an essential component of the T-cell synapse that cooperates with calcineurin to activate the interleukin-2 (IL-2) gene. Several selective functions of PKC theta involved in the activation and survival of T cells are reviewed herein. Among these, the nuclear factor-kappaB (NF-kappaB) signaling cascade appears to be the most critical target of PKC theta in the T-cell receptor/CD28 costimulatory pathway that leads to T-cell activation.
引用
收藏
页码：567 / 573
页数：7
相关论文
共 50 条
  • [31] ALTERED EXPRESSION OF PROTEIN-KINASE-C IN ADULT T-CELL LEUKEMIA-CELLS
    HIDAKA, M
    NAKAKUMA, H
    KAWAGUCHI, T
    NAGAKURA, S
    HORIKAWA, K
    OKUNO, Y
    KAGIMOTO, T
    TAKATSUKI, K
    INTERNATIONAL JOURNAL OF HEMATOLOGY, 1992, 56 (02) : 135 - 141
  • [32] Duplicity of protein kinase C-theta Novel insights into human T-cell biology
    Sutcliffe, Elissa L.
    Rao, Sudha
    TRANSCRIPTION-AUSTIN, 2011, 2 (04): : 189 - 192
  • [33] TRANSCRIPTION OF T-CELL ANTIGEN RECEPTOR GENES IS INDUCED BY PROTEIN KINASE-C ACTIVATION
    LINDSTEN, T
    JUNE, CH
    THOMPSON, CB
    JOURNAL OF IMMUNOLOGY, 1988, 141 (05): : 1769 - 1774
  • [34] Protein Kinase C-θ and vimentin modulate multiple facets of Regulatory T-cell function
    McDonald-Hyman, Cameron
    Thangavelu, Govindarajan
    Saha, Asim
    Muller, James
    Zhang, Guoan
    Kumari, Sudha
    Koehn, Brent H.
    Mitchell, Jason S.
    Fife, Brian T.
    Serody, Jonathan S.
    Osborn, Mark J.
    Hippen, Keli L.
    Kelekar, Ameeta
    Munn, David H.
    Altman, Amnon
    Neubert, Thomas
    Dustin, Michael L.
    Blazar, Bruce R.
    JOURNAL OF IMMUNOLOGY, 2016, 196
  • [35] THE INVOLVEMENT OF PROTEIN-KINASE-C IN ACTIVATION-INDUCED CELL-DEATH IN T-CELL HYBRIDOMA
    JIN, LW
    INABA, K
    SAITOH, T
    CELLULAR IMMUNOLOGY, 1992, 144 (01) : 217 - 227
  • [36] THE ROLE OF PROTEIN-KINASE-C IN THE REGULATION OF EXTRACELLULAR SIGNAL-REGULATED KINASE BY THE T-CELL ANTIGEN RECEPTOR
    IZQUIERDO, M
    LEEVERS, SJ
    WILLIAMS, DH
    MARSHALL, CJ
    WEISS, A
    CANTRELL, D
    EUROPEAN JOURNAL OF IMMUNOLOGY, 1994, 24 (10) : 2462 - 2468
  • [37] GCN2 KINASE IS ESSENTIAL FOR ADAPTIVE T-CELL IMMUNITY IN GLIOMA
    Rashidi, Aida
    Miska, Jason
    Pituch, Katarzyna
    Kanojia, Deepak
    Lopez-Rosas, Aurora
    Han, Yu
    Kim, Julius W.
    Panek, Wojciech K.
    Muroski, Megan
    Lesniak, Maciej S.
    NEURO-ONCOLOGY, 2017, 19 : 113 - 113
  • [38] The role of protein kinase Cη in T cell biology
    Fu, Guo
    Gascoigne, Nicholas R. J.
    FRONTIERS IN IMMUNOLOGY, 2012, 3
  • [39] SYNERGY OF TUMOR-NECROSIS-FACTOR WITH PROTEIN-KINASE C ACTIVATORS ON T-CELL ACTIVATION
    MUNOZFERNANDEZ, MA
    PIMENTELMUINOS, FX
    ALONSO, MA
    CAMPANERO, M
    SANCHEZMADRID, F
    SILVA, A
    ALONSO, JL
    FRESNO, M
    EUROPEAN JOURNAL OF IMMUNOLOGY, 1990, 20 (03) : 605 - 610
  • [40] Protein kinase C θ and ε promote T-cell survival by a rsk-dependent phosphorylation and inactivation of BAD
    Bertolotto, C
    Maulon, L
    Filippa, N
    Baier, G
    Auberger, P
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (47) : 37246 - 37250
12345