Protein kinase Cθ:: a new essential superstar on the T-cell stage

被引：134
|
作者：
Altman, A
Isakov, N
Baier, G
机构：
[1] La Jolla Inst Allergy & Immunol, Div Cell Biol, San Diego, CA 92121 USA
[2] Ben Gurion Univ Negev, Dept Microbiol & Immunol, IL-84105 Beer Sheva, Israel
[3] Univ Innsbruck, Inst Med Biol & Human Genet, A-6020 Innsbruck, Austria
来源：
IMMUNOLOGY TODAY | 2000年 / 21卷 / 11期
关键词：
D O I：
10.1016/S0167-5699(00)01749-7
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Recent studies have identified protein kinase C theta (PKC theta), a member of the Ca2+-independent PKC family as an essential component of the T-cell synapse that cooperates with calcineurin to activate the interleukin-2 (IL-2) gene. Several selective functions of PKC theta involved in the activation and survival of T cells are reviewed herein. Among these, the nuclear factor-kappaB (NF-kappaB) signaling cascade appears to be the most critical target of PKC theta in the T-cell receptor/CD28 costimulatory pathway that leads to T-cell activation.
引用
收藏
页码：567 / 573
页数：7
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