One-pot synthesis of an AZT boranophosphate conjugated with tyrosine: A potential prodrug candidate

被引：5
|
作者：
Li, P [1 ]
Shaw, BR [1 ]
机构：
[1] Duke Univ, Dept Chem, PM Cross Chem Lab, Durham, NC 27708 USA
来源：
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2003年 / 22卷 / 5-8期
关键词：
nucleotide prodrug; boranophosphate; AZT; tyrosine;
D O I：
10.1081/NCN-120022613
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A one-pot synthesis of P-tyrosinyl(P-O)-5'-P-AZT boranophosphate 7 via a phosphoramidite method is described. The P-boranophosphate diastereomers were separated by RP-HPLC, and their structures were confirmed by NMR and MS.
引用
收藏
页码：699 / 701
页数：3
相关论文
共 50 条
  • [1] ONE-POT SYNTHESIS OF CONJUGATED ENYNES
    BARLUENGA, J
    YUS, M
    CONCELLON, JM
    BERNAD, P
    ALVAREZ, F
    JOURNAL OF CHEMICAL RESEARCH-S, 1985, (04): : 128 - 129
  • [2] One-pot synthesis of conjugated alkynenitriles from aldehydes
    Kim, Joong-Gon
    Lee, Eun Hwa
    Jang, Doo Ok
    TETRAHEDRON LETTERS, 2007, 48 (13) : 2299 - 2301
  • [3] One-pot synthesis of conjugated triphenylamine macrocycles and their complexation with fullerenes
    Lu, Ying-Bo
    Kanehashi, Shinji
    Minegishi, Kazushi
    Wang, Shu-Ping
    Cheng, Jin
    Ogino, Kenji
    Li, Shijun
    RSC ADVANCES, 2021, 11 (53) : 33431 - 33437
  • [4] One-Pot Synthesis of Tetraphene and Construction of Expanded Conjugated Aromatics
    Wang, Jianbo
    Yao, Jinzhong
    Wang, Hailong
    Chen, Hao
    Dong, Jingcheng
    Zhou, Hongwei
    JOURNAL OF ORGANIC CHEMISTRY, 2016, 81 (12): : 5250 - 5255
  • [5] One-pot synthesis of hydrogen phosphonate derivatives of d4T and AZT
    Sun, XB
    Kang, JX
    Zhao, YF
    CHEMICAL COMMUNICATIONS, 2002, (20) : 2414 - 2415
  • [6] One-pot synthesis
    Anon
    Chemical and Engineering News, 2002, 80 (46):
  • [7] One-pot synthesis
    Chem Eng News, 5 (29):
  • [8] Unexpected One-Pot Synthesis of Highly Conjugated Pentacyclic Diquinoid Compounds
    Coletti, Alessia
    Lentini, Sara
    Conte, Valeria
    Floris, Barbara
    Bortolini, Olga
    Sforza, Fabio
    Grepioni, Fabrizia
    Galloni, Pierluca
    JOURNAL OF ORGANIC CHEMISTRY, 2012, 77 (16): : 6873 - 6879
  • [9] CATALYTIC OSMYLATION OF CONJUGATED DIENES - A ONE-POT STEREOSELECTIVE SYNTHESIS OF POLYOLS
    PARK, CY
    KIM, BM
    SHARPLESS, KB
    TETRAHEDRON LETTERS, 1991, 32 (08) : 1003 - 1006
  • [10] A general one-pot synthesis of vinyl-thiiranes and conjugated dienes
    Maciagiewicz, I
    Dybowski, P
    Skowronska, A
    POLISH JOURNAL OF CHEMISTRY, 2005, 79 (03) : 515 - 523
12345