One-pot synthesis of an AZT boranophosphate conjugated with tyrosine: A potential prodrug candidate

被引：5
|
作者：
Li, P [1 ]
Shaw, BR [1 ]
机构：
[1] Duke Univ, Dept Chem, PM Cross Chem Lab, Durham, NC 27708 USA
来源：
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2003年 / 22卷 / 5-8期
关键词：
nucleotide prodrug; boranophosphate; AZT; tyrosine;
D O I：
10.1081/NCN-120022613
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A one-pot synthesis of P-tyrosinyl(P-O)-5'-P-AZT boranophosphate 7 via a phosphoramidite method is described. The P-boranophosphate diastereomers were separated by RP-HPLC, and their structures were confirmed by NMR and MS.
引用
收藏
页码：699 / 701
页数：3
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