Therapeuticall approach of obesity in Prader-Willi syndrome

被引：3

作者：

De Carvalho, Daniel F. ^{[1
]}

Cercato, Cintia ^{[1
]}

Almeida, Madson Q. ^{[1
]}

Mancini, Marcio C. ^{[1
]}

Halpern, Alfredo ^{[1
]}

机构：

[1] Univ Sao Paulo, Fac Med, Grp Obesidade & Sindrome Met, Div Endocrinol,Hosp Clin, BR-05508 Sao Paulo, Brazil

来源：

ARQUIVOS BRASILEIROS DE ENDOCRINOLOGIA E METABOLOGIA | 2007年 / 51卷 / 06期

关键词：

obesity; Prader-Willi syndrome; pharmacological treatment; bariatric surgery; topiramate;

D O I：

10.1590/S0004-27302007000600004

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Prader-Willi Syndrome (PWS) is a multisystemic genetic disease characterized by hypotonia, mental retardation, characteristic facial appearance, hyperphagia, and compulsive eating due to hypothalamic dysfunction. PWS is caused by loss of function of genes located in chromosome 15q11-q13, an area subject to genomic imprinting. Obesity is a major cause of increased morbidity and mortality among patients with PWS. The objective of this study was to analyze the therapeutic options available for the treatment of the obesity in PWS including pharmacological and surgical strategies.

引用

页码：913 / 919

页数：7

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