Amniotic Membrane Loading Epidermal Stem Cells Accelerate Impaired Wound Healing in Diabetic Rats

被引：0
|
作者：
Zhong, Qingling [1 ,2 ]
Liu, Dewu [1 ]
Liu, Fanrong [2 ]
机构：
[1] Nanchang Univ, Inst Burns, Affiliated Hosp 1, Nanchang, Peoples R China
[2] Nanchang Univ, Coll Med, Nanchang, Peoples R China
来源：
ADVANCES IN KEY ENGINEERING MATERIALS | 2011年 / 214卷
基金：
中国国家自然科学基金;
关键词：
amniotic membrane; epidermal stem cell; transplantation; wound healing; diabetes mellitus; rat;
D O I：
10.4028/www.scientific.net/AMR.214.455
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
Epidermal stem cells are essential in wound healing, but their amount and activity are decreased in diabetes which contributes to the impaired healing. This study evaluated the efficacy of amniotic membrane loading epidermal stem cells in the management of impaired wound in diabetes. Epidermal stem cells derived from SD rats were isolated, cultured, identified and labled with BrdU in vitro. The wound model of diabetic rats were established, then amniotic membrane loading labled BrdU epidermal stem cells were implanted to impaired wound. The results showed that wound healing rate in amniotic membrane loading epidermal stem cells was significantly higher than that in control groups 14 days after treatment. BrdU-positive cells in the wounds and newborn epidermis were visible. This indicated that amniotic membrane loading epidermal stem cells accelerates epidermal migration of wound margin and wound epithelialization in diabetic rats.
引用
收藏
页码：455 / +
页数：2
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