Wound healing following amniotic membrane, limbal stem cell and corneal transplantation

被引：4

作者：

Messmer, E. M. ^{[1
]}

机构：

[1] Ludwig Maximilians Univ Munchen, Augenklin, Mathildenstr 8, D-80336 Munich, Germany

来源：

OPHTHALMOLOGE | 2020年 / 117卷 / 12期

关键词：

Amniotic membrane; Limbal stem cell deficiency; Limbal stem cell transplantation; Keratoplasty; Limbal epithelial cells; EPITHELIAL TRANSPLANTATION; PENETRATING KERATOPLASTY; BASEMENT-MEMBRANE; SUPPRESSION; NICHE; DIFFERENTIATION; FIBROBLASTS; EXPRESSION; APOPTOSIS; PATTERNS;

D O I：

10.1007/s00347-020-01211-5

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Knowledge of wound healing processes involved in amniotic membrane, limbal stem cell and corneal transplantation enables an assessment of clinical findings and a targeted treatment. The amniotic membrane serves as a basal membrane substrate or temporary transplant in corneal epithelial wound healing. It has an anti-inflammatory effect, supports corneal wound healing and counteracts scar formation. Amniotic membranes are integrated intraepithelially, subepithelially, or intrastromally in the course of healing. Limbal epithelial stem cells express multiple genes necessary for corneal wound healing. The rho-associated, coiled-coil containing protein kinase (ROCK) inhibitor Y-27632 can improve the proliferation of limbal epithelial cells and therefore represents a new therapeutic option for limbal stem cell deficiency. Wound healing following penetrating keratoplasty involves fibroblasts, type III and IV collagens, proteoglycans, and chondroitin-6-sulfate. A certain inflammatory reaction seems to be necessary for final corneal wound closure.

引用

页码：1163 / 1170

页数：8

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