Practical and convenient synthesis of coumarins from phenols and propiolic acid esters

被引：12
|
作者：
Kitamura, Tsugio [1 ]
Oyamada, Juzo [1 ]
Tsubota, Toshiki [2 ]
机构：
[1] Saga Univ, Fac Sci & Engn, Dept Chem & Appl Chem, Honjo, Saga 8408505, Japan
[2] Kyushu Inst Technol, Fac Engn, Dept Mat Sci, Tobata, Kitakyushu 8048502, Japan
来源：
NATURE PROTOCOLS | 2007年 / 2卷 / 04期
关键词：
D O I：
10.1038/nprot.2007.103
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
This protocol describes the synthesis of 6,7-methylenedioxy-4-phenylcoumarin from sesamol and ethyl phenylpropiolate using a Pd(OAc)(2) catalyst to illustrate coumarin synthesis. This procedure is simple and easy and can be applied to the synthesis of other coumarins that have electron-rich phenol groups. The reaction is conducted by stirring a solution of Pd( OAc)(2), sesamol and ethyl phenylpropiolate in trifluoroacetic acid at room temperature (15-20 degrees C) under atmospheric conditions. This protocol can be completed in 3 d.
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页码：845 / +
页数：5
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