Practical and convenient synthesis of coumarins from phenols and propiolic acid esters

被引：12

作者：

Kitamura, Tsugio ^{[1
]}

Oyamada, Juzo ^{[1
]}

Tsubota, Toshiki ^{[2
]}

机构：

[1] Saga Univ, Fac Sci & Engn, Dept Chem & Appl Chem, Honjo, Saga 8408505, Japan

[2] Kyushu Inst Technol, Fac Engn, Dept Mat Sci, Tobata, Kitakyushu 8048502, Japan

来源：

NATURE PROTOCOLS | 2007年 / 2卷 / 04期

关键词：

D O I：

10.1038/nprot.2007.103

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

This protocol describes the synthesis of 6,7-methylenedioxy-4-phenylcoumarin from sesamol and ethyl phenylpropiolate using a Pd(OAc)(2) catalyst to illustrate coumarin synthesis. This procedure is simple and easy and can be applied to the synthesis of other coumarins that have electron-rich phenol groups. The reaction is conducted by stirring a solution of Pd( OAc)(2), sesamol and ethyl phenylpropiolate in trifluoroacetic acid at room temperature (15-20 degrees C) under atmospheric conditions. This protocol can be completed in 3 d.

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页码：845 / +

页数：5

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