Ytterbium triflate promoted coupling of phenols and propiolic acids: synthesis of coumarins

被引：22
|
作者：
Fiorito, Serena [1 ]
Epifano, Francesco [1 ]
Taddeo, Vito A. [1 ]
Genovese, Salvatore [1 ]
机构：
[1] Univ G dAnnunzio, Dipartimento Farm, Via Vestini 31, I-66100 Chieti, CH, Italy
来源：
TETRAHEDRON LETTERS | 2016年 / 57卷 / 26期
关键词：
Catalysis; Coumarins; Lanthanides; Microwave irradiation; Ytterbium triflate; ONE-POT SYNTHESIS; PECHMANN REACTION; CATALYSTS; CONDENSATION; DERIVATIVES; WARFARIN;
D O I：
10.1016/j.tetlet.2016.05.087
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Coumarins are a well-known class of natural occurring and semi-synthetic products with reported important and effective pharmacological activities. In this Letter an improved method for the chemical synthesis of such compounds is described. Coumarins have been obtained in good to excellent yields under microwave irradiation and solvent-free conditions in a short time from differently substituted phenols and propiolic acids used as starting materials in the presence of Yb(OTf)(3) hydrate 10% mol as the catalyst. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2939 / 2942
页数：4
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