Regulating the Timing of CENP-A Nucleosome Assembly by Phosphorylation

被引:3
|
作者
Miell, Matthew D. D. [1 ]
Straight, Aaron F. [1 ]
机构
[1] Stanford Univ, Dept Biochem, Sch Med, Stanford, CA 94305 USA
关键词
CENTROMERIC CHROMATIN; HJURP; MIS18;
D O I
10.1016/j.devcel.2014.12.020
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
In this issue of Developmental Cell, Yu et al. (2015) demonstrate that CENP-A phosphorylation by CDK1 inhibits its association with the chaperone protein HJURP and that the removal of this modification at mitotic exit is a key regulatory event that controls the timing of new CENP-A nucleosome formation at centromeres.
引用
收藏
页码:1 / 2
页数:2
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