Chiral phosphoric acid catalyzed enantioselective Friedel-Crafts alkylation of indoles with nitroalkenes:: Cooperative effect of 3 Å molecular sieves

被引：277
|
作者：
Itoh, Junji [1 ]
Fuchibe, Kohei [1 ]
Akiyama, Takahiko [1 ]
机构：
[1] Gakushuin Univ, Fac Sci, Dept Chem, Toshima Ku, Tokyo 1718588, Japan
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 21期
关键词：
asymmetric synthesis; Bronsted acids; enantioselectivity; Friedel-Crafts alkylation; indoles;
D O I：
10.1002/anie.200800770
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Chemical Equation Presented) Crafty catalysts: Friedel-Crafts alkylation of indoles with nitroalkenes proceeded in the presence of phosphoric acid 1 and 3 Å molecular sieves to give Friedel-Crafts adducts with excellent enantioselectivities (see scheme). © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：4016 / 4018
页数：3
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